2. Gene
  3. Map2k5 - mitogen activated protein kinase kinase 5 Gene

Map2k5 - mitogen activated protein kinase kinase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：有丝分裂原活化蛋白激酶激酶 5

种属: Rattus norvegicus

同用名: Mek5

基因 ID: 29568 | 基因类型: protein coding

关于 Map2k5

Primary_assembly 8: 63,625,221-63,851,983 reverse strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 9 phenotypes.

功能概要

该基因编码的蛋白可启动 ATP 结合活性和蛋白激酶活性。涉及多个进程，包括ERK5级联；细胞凋亡过程的负调控；和基因表达的调控。位于细胞质和细胞核中。与人 MAP2K5（丝裂原活化蛋白激酶激酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of gene expression. Located in cytosol and nucleus. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map2k5 基因产物(2)

mRNA Protein Name
NM_001033987.1 NP_001029159.1 dual specificity mitogen-activated protein kinase kinase 5 isoform a
NM_017246.2 NP_058942.1 dual specificity mitogen-activated protein kinase kinase 5 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
7499418 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
7499418 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERK5 cascade IMP
IMP: 通过突变表型推断
15631999 RGD
involved in MAPK cascade IMP
IMP: 通过突变表型推断
20551324 RGD
involved in cellular response to growth factor stimulus IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of heterotypic cell-cell adhesion IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of response to cytokine stimulus IMP
IMP: 通过突变表型推断
20551324 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: 通过突变表型推断
20724525 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20551324 RGD
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
15623435 RGD
involved in positive regulation of epithelial cell proliferation IDA
IDA: 通过直接分析推断
15631999 RGD
involved in positive regulation of protein metabolic process IMP
IMP: 通过突变表型推断
20551324 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20551324 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
7499418 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dual specificity mitogen-activated protein kinase kinase 5

MAP kinase kinase 5

MAPK/ERK kinase 5

MAPKK 5

MEK 5

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08041 MAP2K5 Human Pre-designed siRNA Set A / 否
HY-RS08042 Map2k5 Mouse Pre-designed siRNA Set A / 否
HY-RS08043 Map2k5 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map2k5 NCBI NCBI:5607
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