Il17a - interleukin 17A Gene

中文名称：白细胞介素 17A

种属: Rattus norvegicus

同用名: Il17; IL-17; CTLA-8; IL-17A

关于 Il17a

功能概要

预测该基因编码的蛋白能够实现蛋白质异二聚化活性和蛋白质同二聚化活性。参与多个过程，包括细胞对糖皮质激素刺激的反应；坏死细胞死亡的正调节；和 RNA 聚合酶 II 对转录的正调控。位于细胞质和细胞外空间。用于研究抗基底膜肾小球肾炎；充血性心力衰竭;心肌炎;胸膜炎;和葡萄膜炎。多种疾病的生物标志物，包括急性坏死性胰腺炎；炎症性肠病（多发性）；类脂性肾病;肺部疾病（多发）；和牙周病（多种）。该基因的人类直系同源物与鸟分枝杆菌复杂疾病有关；自身免疫性疾病（多种）；支气管疾病（多发）；黄斑变性;和鼻炎（多种）。与人 IL17A（白细胞介素 17A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A). [provided by Alliance of Genome Resources, Apr 2022]