Il17a - interleukin 17A Gene

中文名称：白细胞介素 17A

种属: Mus musculus

同用名: Il17; Ctla8; IL-17; Ctla-8; IL-17A

关于 Il17a

功能概要

该基因编码一种促炎细胞因子，它是白细胞介素 17 家族的一员。编码的蛋白质在宿主防御多种病原体中起着核心作用。编码的蛋白质由活化的 T 细胞和先天免疫系统的某些细胞类型产生。活性蛋白作为与其他白细胞介素 17 家族成员的同型二聚体发挥作用，并通过白细胞介素 17 受体发出信号以诱导炎性细胞因子的产生。该基因的异常表达与自身炎症性疾病有关，包括类风湿性关节炎、牛皮癣和多发性硬化症。 [RefSeq 提供，2015 年 9 月]

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]