ABL1 - ABL proto-oncogene 1, non-receptor tyrosine kinase Gene

中文名称：ABL 原癌基因 1 ， 非受体酪氨酸激酶

种属: Rattus norvegicus

同用名: Abl

关于 ABL1

功能概要

该基因编码的蛋白可启动 delta-catenin 绑定活动；蛋白激酶活性；和蛋白激酶结合活性。参与多个过程，包括肾小球脏层上皮细胞凋亡过程；细胞成分组织的正调控；和程序性细胞死亡的正调节。位于多个细胞成分中，包括生长锥；神经细胞体；和荷叶边。帕金森病和输尿管梗阻的生物标志物。该基因的人类直系同源物与胃肠道系统癌症有关（多个）；白血病（多发性）；和肺非小细胞癌。与人类 ABL1（ABL 原癌基因 1，非受体酪氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables delta-catenin binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including glomerular visceral epithelial cell apoptotic process; positive regulation of cellular component organization; and positive regulation of programmed cell death. Located in several cellular components, including growth cone; neuronal cell body; and ruffle. Biomarker of Parkinson's disease and ureteral obstruction. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]