2. Gene
  3. ABL1 - ABL proto-oncogene 1, non-receptor tyrosine kinase Gene

ABL1 - ABL proto-oncogene 1, non-receptor tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ABL 原癌基因 1 ， 非受体酪氨酸激酶

种属: Rattus norvegicus

同用名: Abl

基因 ID: 311860 | 基因类型: protein coding

关于 ABL1

Primary_assembly 3: 14,979,853-15,083,065 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 204 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in Kidney (RPKM 15.7), Lung (RPKM 94.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 delta-catenin 绑定活动；蛋白激酶活性；和蛋白激酶结合活性。参与多个过程，包括肾小球脏层上皮细胞凋亡过程；细胞成分组织的正调控；和程序性细胞死亡的正调节。位于多个细胞成分中，包括生长锥；神经细胞体；和荷叶边。帕金森病和输尿管梗阻的生物标志物。该基因的人类直系同源物与胃肠道系统癌症有关（多个）；白血病（多发性）；和肺非小细胞癌。与人类 ABL1（ABL 原癌基因 1，非受体酪氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables delta-catenin binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including glomerular visceral epithelial cell apoptotic process; positive regulation of cellular component organization; and positive regulation of programmed cell death. Located in several cellular components, including growth cone; neuronal cell body; and ruffle. Biomarker of Parkinson's disease and ureteral obstruction. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

ABL1 基因产物(1)

mRNA Protein Name
NM_001100850.1 NP_001094320.1 tyrosine-protein kinase ABL1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables delta-catenin binding IDA
IDA: 通过直接分析推断
11891774 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10679771 RGD
enables protein kinase activity IMP
IMP: 通过突变表型推断
15629889 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
19700222 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament polymerization IMP
IMP: 通过突变表型推断
17615370 RGD
involved in associative learning IEP
IEP: 通过表达模式推断
23532861 RGD
involved in cardiac muscle cell proliferation IEP
IEP: 通过表达模式推断
2447874 RGD
involved in cellular response to oxidative stress IEP
IEP: 通过表达模式推断
20883783 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
15629889 RGD
involved in learning or memory IMP
IMP: 通过突变表型推断
18559370 RGD
involved in myoblast proliferation IEP
IEP: 通过表达模式推断
2425941 RGD
involved in podocyte apoptotic process IMP
IMP: 通过突变表型推断
23515840 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15474370 RGD
involved in positive regulation of dendrite development IMP
IMP: 通过突变表型推断
15456825 RGD
involved in positive regulation of extracellular matrix organization IMP
IMP: 通过突变表型推断
19846571 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
19846571 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
18559370 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
17615370 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
9583675 RGD
involved in regulation of modification of synaptic structure IGI
IGI: 通过遗传相互作用推断
24658113 RGD
involved in regulation of postsynaptic specialization assembly EXP
EXP: 通过实验结果推断
20220006 RGD
involved in regulation of postsynaptic specialization assembly IDA
IDA: 通过直接分析推断
20220006 RGD
involved in regulation of postsynaptic specialization assembly IMP
IMP: 通过突变表型推断
20220006 RGD
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
11509666 RGD
involved in response to epinephrine IEP
IEP: 通过表达模式推断
2166578 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
20519366 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
24658113 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
20220006 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20220006 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
20220006 RGD
located in growth cone IDA
IDA: 通过直接分析推断
11891774 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
24412932 RGD
located in nucleus IDA
IDA: 通过直接分析推断
24658113 RGD
is active in postsynaptic density EXP
EXP: 通过实验结果推断
20220006 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
20220006 RGD
is active in postsynaptic density IMP
IMP: 通过突变表型推断
20220006 RGD
located in ruffle IDA
IDA: 通过直接分析推断
16831423 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ABL1 蛋白结构

SH3_Abl

SH3_Abl: cd11850 (83 - 136)

SH2_ABL

SH2_ABL: cd09935 (141 - 234)

PTKc_Abl

PTKc_Abl: cd05052 (253 - 515)

FABD

FABD: smart00808 (1018 - 1142)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1143 a.a.
蛋白主名 其他名称

tyrosine-protein kinase ABL1

Abelson murine leukemia viral (v-abl) oncogene homolog 1

c-abl oncogene 1, non-receptor tyrosine kinase

c-abl oncogene 1, receptor tyrosine kinase

tyrosine-protein kinase ABL1-like

v-abl Abelson murine leukemia viral oncogene 1

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-104010 Asciminib Inhibitor 99.88% 是
HY-15728 Radotinib 98.92% 是
HY-104010A Asciminib hydrochloride Inhibitor 99.84% 是
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-13024 Rebastinib 99.91% Phase 2
HY-137460 Vodobatinib Inhibitor 99.85% Phase 2
HY-148794 Risvodetinib Inhibitor 99.21% Phase 2
HY-13072 Cenisertib Inhibitor 99.86% Phase 1
Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125845 (S,R,S)-AHPC 99.13% 否
HY-125834 GMB-475 98.98% 否
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.34% 否
HY-W143698 PDGFRα kinase inhibitor 2 Inhibitor 98.95% 否
HY-12338 ON 146040 Inhibitor 95.05% 否
HY-107447S N-Deshydroxyethyl Dasatinib-d8 / 否
HY-101268 CHMFL-ABL-053 Inhibitor / 否
HY-101763B (S,R,S)-AHPC dihydrochloride / 否
HY-119177 PD173956 Inhibitor / 否
HY-130297 PROTAC BCR-ABL1 ligand 1 Inhibitor / 否
HY-145887 BCR-ABL1-IN-1 99.82% 否
HY-14979 ML786 Inhibitor / 否
HY-14979A ML786 dihydrochloride Inhibitor / 否
HY-155112 Antiproliferative agent-30 Inhibitor / 否
HY-15728S Radotinib-d6 / 否
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / 否
HY-162489 Tyrosine kinase-IN-8 Inhibitor / 否
HY-162952 cSRC/BCR-ABL1-IN-1 Inhibitor / 否
HY-RS00102 ABL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00103 Abl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00104 ABL1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-13072B Cenisertib benzoate Inhibitor / 否
HY-110402 (S,R,S)-AHPC TFA / 否
HY-18819 BCR-ABL-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ABL1 NCBI NCBI:25
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z