2. Gene
  3. Abcg2 - ATP binding cassette subfamily G member 2 Gene

Abcg2 - ATP binding cassette subfamily G member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ATP 结合盒亚家族 G 成员 2

种属: Rattus norvegicus

同用名: Bcrp; BCRP1

基因 ID: 312382 | 基因类型: protein coding

关于 Abcg2

Primary_assembly 4: 87,745,319-87,802,409 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 312 orthologues, 9 paralogues and is associated with 38 phenotypes. Biased expression in Kidney (RPKM 256.7), Brain (RPKM 36.1) and 6 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括细胞骨架蛋白结合活性；流出跨膜转运蛋白活性；和外源性跨膜转运蛋白活性。参与多个过程，包括细胞对脂质的反应；参与女性妊娠的胚胎过程；和尿酸盐排泄。位于顶端质膜和细胞核的外侧。糖尿病生物标志物；继发性甲状旁腺功能亢进症;癫痫持续状态；和 2 型糖尿病。该基因的人类直系同源物与痛风有关；血液系统癌症（多发性）；肾细胞癌；和中毒性脑病。与人类 ABCG2 同源（ATP 结合盒亚家族 G 成员 2（初级血型））。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including cytoskeletal protein binding activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to lipid; embryonic process involved in female pregnancy; and urate salt excretion. Located in external side of apical plasma membrane and nucleus. Biomarker of diabetes mellitus; secondary hyperparathyroidism; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in gout; hematologic Cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Abcg2 基因产物(1)

mRNA Protein Name
NM_181381.2 NP_852046.1 broad substrate specificity ATP-binding cassette transporter ABCG2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amide transmembrane transporter activity IDA
IDA: 通过直接分析推断
15255930 RGD
enables cytoskeletal protein binding IPI
IPI: 通过物理相互作用推断
23403943 RGD
enables efflux transmembrane transporter activity IDA
IDA: 通过直接分析推断
15773906 RGD
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
15773906 RGD
enables xenobiotic transmembrane transporter activity IDA
IDA: 通过直接分析推断
15773906 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
18524938 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
23592396 RGD
involved in embryonic process involved in female pregnancy IDA
IDA: 通过直接分析推断
18450391 RGD
involved in export across plasma membrane IDA
IDA: 通过直接分析推断
15773906 RGD
involved in negative regulation of intestinal absorption IMP
IMP: 通过突变表型推断
23333829 RGD
involved in organic anion transport IDA
IDA: 通过直接分析推断
15773906 RGD
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
15255930 RGD
involved in renal urate salt excretion IEP
IEP: 通过表达模式推断
28679589 RGD
involved in response to 2,3,7,8-tetrachlorodibenzodioxine IEP
IEP: 通过表达模式推断
22472606 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
29978425 RGD
involved in response to folic acid IEP
IEP: 通过表达模式推断
19552531 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
28679589 RGD
involved in response to iron ion IEP
IEP: 通过表达模式推断
15637178 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
18505788 RGD
involved in transmembrane transport IMP
IMP: 通过突变表型推断
16809480 RGD
involved in urate transport IMP
IMP: 通过突变表型推断
22348008 RGD
involved in xenobiotic detoxification by transmembrane export across the plasma membrane IDA
IDA: 通过直接分析推断
15255930 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
18451542 RGD
located in external side of apical plasma membrane IDA
IDA: 通过直接分析推断
18619525 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Abcg2 蛋白结构

3a01204

3a01204: cl36780 (45 - 650)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
蛋白主名 其他名称

broad substrate specificity ATP-binding cassette transporter ABCG2

ATP binding cassette subfamily G member 2 (Junior blood group)

ATP-binding cassette protein G2

ATP-binding cassette sub-family G member 2

ATP-binding cassette, sub-family G (WHITE), member 2

ATP-binding cassette, subfamily G (WHITE), member 2

breast cancer resistance protein 1 homolog

urate exporter

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10440 Vismodegib 99.97% 是
HY-101561 Avapritinib Inhibitor 99.94% 是
HY-B1153A Glafenine hydrochloride Antagonist 99.25% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-109019 Vorolanib Inhibitor 99.88% Phase 3
HY-10527C Telatinib mesylate Inhibitor 99.74% Phase 2
Pre-clinical Phase
生物活性分子 (38)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10010 Ko 143 Inhibitor 99.97% 否
HY-11079 A-803467 Inhibitor 99.09% 否
HY-N2143 Fumitremorgin C Inhibitor 99.90% 否
HY-101453 Ceefourin 1 Inhibitor 99.72% 否
HY-12757 YHO-13177 Inhibitor 98.45% 否
HY-18010 PCI 29732 Inhibitor 99.86% 否
HY-144305 KPH2f Inhibitor 99.22% 否
HY-100933 MY-5445 Inhibitor 99.86% 否
HY-111678 ML230 Inhibitor 99.60% 否
HY-112505 Efflux inhibitor-1 Inhibitor ≥98.0% 否
HY-113805 MC70 Inhibitor 99.50% 否
HY-136450 Triclabendazole sulfoxide Inhibitor 98.78% 否
HY-151432 URAT1 inhibitor 3 Inhibitor 98.02% 否
HY-103439 GW583340 dihydrochloride Inhibitor / 否
HY-121645 2,4-Dibromoestradiol / 否
HY-122416 6,8-Diprenylnaringenin Inhibitor / 否
HY-129301 CCTA-1523 Inhibitor / 否
HY-136450S Triclabendazole sulfoxide-d3 Inhibitor / 否
HY-136450S1 Triclabendazole sulfoxide-13C,d3 Inhibitor / 否
HY-146676 UR-MB108 Inhibitor / 否
HY-155652 ABCG2-IN-1 Inhibitor / 否
HY-155653 ABCG2-IN-2 Inhibitor / 否
HY-156092 Antitumor photosensitizer-4 / 否
HY-163919 N,N-Dimethyl-idarubicin-trisaccharide / 否
HY-168572 MZ82 Inhibitor / 否
HY-168573 AZ99 Inhibitor / 否
HY-170396 ABCG2-IN-4 Inhibitor / 否
HY-P5391 LL-37(17-32) Inhibitor / 否
HY-RS00077 ABCG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00078 Abcg2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00079 Abcg2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W082856A Butein tetramethyl ether Inhibitor / 否
HY-119724 ABCG2-IN-3 Inhibitor / 否
HY-123526 NSC265473 / 否
HY-149469 3,7,2',4'-Tetramethoxy-5-hydroxyflavone Inhibitor / 否
HY-N2651 5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone Inhibitor / 否
HY-W705354 Vismodegib-d4 / 否
HY-W716916 Vismodegib-d7 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abcg2 NCBI NCBI:9429
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验，部分功能也使用 Cookies 帮助我们更好地理解您的需求，为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问，请阅读我们的《隐私声明》。

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z