2. Gene
  3. HOXA5 - homeobox A5 Gene

HOXA5 - homeobox A5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：同源框 A5

种属: Homo sapiens

同用名: HOX1; HOX1C; HOX1.3

基因 ID: 3202 | 基因类型: protein coding

关于 HOXA5

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,141,052-27,143,681 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 42 paralogues. Biased expression in adrenal (RPKM 48.1), lung (RPKM 14.3) and 8 other tissues.

功能概要

在脊椎动物中，编码称为同源盒基因的转录因子类的基因位于四个独立染色体上名为 A、B、C 和 D 的簇中。这些蛋白质的表达在胚胎发育过程中受到时空调控。该基因是 7 号染色体 A 簇的一部分，编码 DNA 结合转录因子，可调节基因表达、形态发生和分化。该基因的甲基化可能导致其表达缺失，并且由于编码的蛋白质上调肿瘤抑制因子 p53，该蛋白质可能在肿瘤发生中发挥重要作用。[RefSeq 提供，2008 年 7 月]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]

HOXA5 基因产物(1)

mRNA Protein Name
NM_019102.4 NP_061975.2 homeobox protein Hox-A5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
8657138 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10879542 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
10879542 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10879542 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15545268 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
17957028 GOA
involved in negative regulation of erythrocyte differentiation IDA
IDA: 通过直接分析推断
10397719 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
10879542 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
10875927 GOA
involved in positive regulation of myeloid cell differentiation IDA
IDA: 通过直接分析推断
10397719 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10879542 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15545268 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOXA5 蛋白结构

Homeobox

Homeobox: Homeobox domain (196 - 252)

  • 0
  • 100
  • 200
  • 270 a.a.
蛋白主名 其他名称

homeobox protein Hox-A5

homeo box 1C

HOXA5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HOXA5 P20719 CTBP2 Homo sapiens P56545-3
Validated Y2H
32296183
种属内
HOXA5 P20719 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
种属内
HOXA5 P20719 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
种属内
HOXA5 P20719 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
种属内
HOXA5 P20719 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
种属内
HOXA5 P20719 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
种属内
HOXA5 P20719 PBX2 Homo sapiens P40425
Validated Y2H
32296183
种属内
HOXA5 P20719 PBX2 Homo sapiens P40425
Y2H Array
32296183
种属内
HOXA5 P20719 PBX2 Homo sapiens P40425
Y2H Prey Pooling
32296183
种属内
HOXA5 P20719 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
HOXA5 P20719 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
HOXA5 P20719 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
HOXA5 P20719 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
种属内
HOXA5 P20719 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
种属内
HOXA5 P20719 DVL3 Homo sapiens Q92997
Y2H Array
32296183
种属内
HOXA5 P20719 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属内
HOXA5 P20719 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

HOXA5 抗体

目录号 产品名 应用 反应物种
HY-P83162 HOXA5 Antibody (YA2907) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal
Cardiomyopathy, Familial Hypertrophic, 20

Hypertrophic Cardiomyopathy 20

CMH20

Cardiomyopathy, Hypertrophic, 20

Cardiomyopathy Familial Hypertrophic 20

Cardiomyopathy, Familial Hypertrophic 20

Cardiomyopathy, Hypertrophic, Familial, Type 20
Mediastinal Gray Zone Lymphoma

Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma

Lymphoma Of Mediastinum

Mediastinal Lymphoma
Clubfoot

Congenital Talipes Equinovarus

Congenital Clubfoot

Congenital Equinovarus

Equinovarus Deformity Of Foot

Club Foot
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06300 HOXA5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus HOXA5 VGNC VGNC:29913
Macaca mulatta HOXA5 VGNC VGNC:108414
Felis catus HOXA5 VGNC VGNC:102601
Canis familiaris HOXA5 VGNC VGNC:54769
Mus musculus HOXA5 MGD MGI:96177
Rattus norvegicus HOXA5 RGD RGD:620609
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