Ep300 - E1A binding protein p300 Gene

中文名称：E1A 结合蛋白 p300

种属: Mus musculus

同用名: p300; KAT3B; p300 HAT; A430090G16; A730011L11

关于 Ep300

功能概要

该基因编码的蛋白可启动多种功能，包括 N-酰基转移酶活性；核酸结合活性；和 p53 结合活性。涉及多个过程，包括面部形态发生；参与未折叠蛋白反应的 RNA 聚合酶 II 启动子转录的正调控；和蛋白质酰化。作用于多个过程的上游或内部，包括动物器官发育；组蛋白 H3-K56 乙酰化；和基因表达的调控。组蛋白乙酰转移酶复合物和转录调节复合物的一部分。以多种结构表达，包括消化系统；心;肺;神经系统;和皮肤。用于研究系统性红斑狼疮。该基因的人类直系同源物与 Rubinstein-Taybi 综合征有关；结直肠癌；和充血性心力衰竭。与人 EP300（E1A 结合蛋白 p300）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including N-acyltransferase activity; nucleic acid binding activity; and p53 binding activity. Involved in several processes, including face morphogenesis; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; and protein acylation. Acts upstream of or within several processes, including animal organ development; histone H3-K56 acetylation; and regulation of gene expression. Part of Histone Acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including alimentary system; heart; lung; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Apr 2022]