1. Gene
  2. Ulk1 - unc-51 like autophagy activating kinase 1 Gene

Ulk1 - unc-51 like autophagy activating kinase 1 Gene

中文名称:unc-51 样自噬激活激酶 1

种属: Rattus norvegicus

基因 ID: 360827 | 基因类型: protein coding

关于 Ulk1

Primary_assembly 12: 45,851,710-45,877,966 forward strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 3 phenotypes. Biased expression in Heart (RPKM 81.8), Adrenal (RPKM 77.1) and 9 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能,包括 HSP90 蛋白结合活性;酶结合活性;和相同的蛋白质结合活性。参与神经元投射再生和自噬体组装的正调控。位于轴突。用于研究粘膜炎。与人类 ULK1(unc-51 样自噬激活激酶 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including HSP90 protein binding activity; Enzyme binding activity; and identical protein binding activity. Involved in neuron projection regeneration and positive regulation of autophagosome assembly. Located in axon. Used to study mucositis. Orthologous to human ULK1 (unc-51 like Autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ulk1 基因产物(1)

mRNA Protein Name
NM_001108341.1 NP_001101811.1 serine/threonine-protein kinase ULK1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neuron projection development IMP
IMP: 通过突变表型推断
18007665 RGD
involved in neuron projection regeneration IMP
IMP: 通过突变表型推断
18007665 RGD
involved in positive regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
23448468 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
25040536 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ulk1 蛋白结构

STKc_ULK1

STKc_ULK1: cd14202 (12 - 278)

DUF3543

DUF3543: cl13493 (843 - 1050)

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  • 1057 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase ULK1

unc-51-like kinase 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ulk1 NCBI NCBI:8408