2. Gene
  3. ASGR1 - asialoglycoprotein receptor 1 Gene

ASGR1 - asialoglycoprotein receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：去唾液酸糖蛋白受体 1

种属: Homo sapiens

同用名: HL-1; ASGPR; ASGPR1; CLEC4H1

基因 ID: 432 | 基因类型: protein coding

关于 ASGR1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,173,431-7,179,370 (from NCBI)

This gene has 9 transcripts (splice variants), 155 orthologues and 14 paralogues. Biased expression in liver (RPKM 145.0) and testis (RPKM 4.7).

功能概要

该基因编码脱唾液酸糖蛋白受体的一个亚基。该受体是一种跨膜蛋白，通过介导具有暴露的末端半乳糖或 N-乙酰半乳糖胺残基的糖蛋白的内吞作用和溶酶体降解，在血清糖蛋白稳态中起关键作用。脱唾液酸糖蛋白受体可能促进包括乙型肝炎在内的多种病毒对肝脏的感染，并且也是肝脏特异性药物递送的靶标。脱唾液酸糖蛋白受体是由不同基因编码的主要和次要亚基组成的异源寡聚蛋白。该基因编码的蛋白质是更丰富的主要亚基。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 1 月]

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic Infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASGR1 基因产物(2)

mRNA Protein Name
NM_001197216.3 NP_001184145.1 asialoglycoprotein receptor 1 isoform b
NM_001671.5 NP_001662.1 asialoglycoprotein receptor 1 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASGR1 蛋白结构

Lectin_N

Lectin_N: Hepatic lectin, N-terminal domain (6 - 144)

Lectin_C

Lectin_C: Lectin C-type domain (172 - 279)

  • 0
  • 100
  • 200
  • 291 a.a.
蛋白主名 其他名称

asialoglycoprotein receptor 1

C-type lectin domain family 4 member H1

ASGR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ASGR1 P07306 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
种属内
ASGR1 P07306 CERS2 Homo sapiens Q96G23
Y2H
21988832
种属内
ASGR1 P07306 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
种属内
ASGR1 P07306 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
种属内
ASGR1 P07306 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
种属内
ASGR1 P07306 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 HIBADH Homo sapiens P31937
Validated Y2H
32296183
种属内
ASGR1 P07306 HIBADH Homo sapiens P31937
Y2H Array
32296183
种属内
ASGR1 P07306 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
种属内
ASGR1 P07306 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
种属内
ASGR1 P07306 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Array
32296183
种属内
ASGR1 P07306 AHNAK2 Homo sapiens Q8IVF2-3
Validated Y2H
32296183
种属内
ASGR1 P07306 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
种属内
ASGR1 P07306 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
种属内
ASGR1 P07306 ATP1B4 Homo sapiens Q9UN42
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 ATP1B4 Homo sapiens Q9UN42
Validated Y2H
32296183
种属内
ASGR1 P07306 ATP1B4 Homo sapiens Q9UN42
Y2H Array
32296183
种属内
ASGR1 P07306 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
种属内
ASGR1 P07306 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
种属内
ASGR1 P07306 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
种属内
ASGR1 P07306 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
种属内
ASGR1 P07306 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
种属内
ASGR1 P07306 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
种属内
ASGR1 P07306 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 SUSD3 Homo sapiens Q96L08
Validated Y2H
32296183
种属内
ASGR1 P07306 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
ASGR1 P07306 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
种属内
ASGR1 P07306 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
种属内
ASGR1 P07306 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
种属内
ASGR1 P07306 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
种属内
ASGR1 P07306 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
种属内
ASGR1 P07306 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 APH1A Homo sapiens Q96BI3
Validated Y2H
32296183
种属内
ASGR1 P07306 APH1A Homo sapiens Q96BI3
Y2H Array
32296183
种属内
ASGR1 P07306 APH1A Homo sapiens Q96BI3
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 MCEMP1 Homo sapiens Q8IX19
Validated Y2H
32296183
种属内
ASGR1 P07306 MCEMP1 Homo sapiens Q8IX19
Y2H Array
32296183
种属内
ASGR1 P07306 MCEMP1 Homo sapiens Q8IX19
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 FCGR1A Homo sapiens P12314
Y2H Array
32296183
种属内
ASGR1 P07306 FCGR1A Homo sapiens P12314
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 FCGR1A Homo sapiens P12314
Validated Y2H
32296183
种属内
ASGR1 P07306 BLCAP Homo sapiens P62952
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 BLCAP Homo sapiens P62952
Validated Y2H
32296183
种属内
ASGR1 P07306 BLCAP Homo sapiens P62952
Y2H Array
32296183
种属内
ASGR1 P07306 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
种属内
ASGR1 P07306 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
种属内
ASGR1 P07306 SLC10A1 Homo sapiens Q14973
Validated Y2H
32296183
种属内
ASGR1 P07306 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
种属内
ASGR1 P07306 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
种属内
ASGR1 P07306 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
种属内
ASGR1 P07306 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
种属内
ASGR1 P07306 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
ASGR1 P07306 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
种属内
ASGR1 P07306 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
种属内
ASGR1 P07306 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
种属内
ASGR1 P07306 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 CLDN7 Homo sapiens O95471
Y2H Array
32296183
种属内
ASGR1 P07306 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
种属内
ASGR1 P07306 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
种属内
ASGR1 P07306 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
种属内
ASGR1 P07306 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属内
ASGR1 P07306 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
种属内
ASGR1 P07306 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
种属内
ASGR1 P07306 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ASGR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7610 ASGR1/ASGPR1 Protein, Human (HEK293, His) P07306 (Q62-L291) ≥95%

ASGR1 抗体

目录号 产品名 应用 反应物种
HY-P81553 ASGPR Antibody (YA1298) WB, IHC-P, ICC/IF, FC, IP Human

关联疾病

疾病名称 别名
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Hepatitis E
Autoimmune Hepatitis

Aih

Hepatitis, Autoimmune

Autoimmune Chronic Active Hepatitis

Autoimmune Hepatitis With Centrilobular Necrosis

Autoimmune Chronic Hepatitis

Hepatitis Autoimmune
Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix
Amelogenesis Imperfecta, Type Ib

AI1B

Aih2

Amelogenesis Imperfecta Type 1b

Amelogenesis Imperfecta Type Ib

Hereditary Localized Enamel Hypoplasia

Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local

Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant

Enamel Hypoplasia, Hereditary Localized

Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta

Amelogenesis Imperfecta 1b

Amelogenesis Imperfecta Hypoplastic 2

Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant
Amelogenesis Imperfecta, Type Ie

Aih1

Amelogenesis Imperfecta Type 1e

AI1E

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

Enamel Hypoplasia, X-Linked

Amelogenesis Imperfecta Type Ie

Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

Enamel Hypoplasia X-Linked

Amelogenesis Imperfecta, X-Linked 1

Amelogenesis Imperfecta, Type 1e

Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

X-Linked Amelogenesis Imperfecta 1

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

X-Linked Enamel Hypoplasia

Amelogenesis Imperfecta X-Linked 1

Amelogenesis Imperfecta 1e

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

Xai

X-Linked Amelogenesis Imperfecta

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Acute Cervicitis
Amyloidosis, Hereditary, Transthyretin-Related

Transthyretin Amyloidosis

Familial Amyloid Polyneuropathy

Ttr Amyloid Neuropathy

Transthyretin Amyloid Neuropathy

Transthyretin Amyloid Polyneuropathy

Fap

Familial Transthyretin Amyloidosis

Amyloidosis Transthyretin Related

Type I Familial Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy Type I

Attrv122i Amyloidosis

Hereditary Amyloidosis, Transthyretin-Related

Amyloid Polyneuropathy, Familial

Attr Amyloidosis

Attrm Amyloidosis

Corino De Andrade'S Disease

Paramyloidosis

Transthyretin-Related Hereditary Amyloidosis

Ttr Amyloidosis

Hereditary Attr Amyloidosis

Portuguese Polyneuritic Amyloidosis

Portuguese Type Familial Amyloid Neuropathy

Swiss Type Amyloid Polyneuropathy

Type Ii Familial Amyloid Polyneuropathy

Attrv30m Amyloidosis

Attrv30m-Related Amyloidosis

Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type

Attr Cardiomyopathy

Attrv122i-Related Amyloidosis

Ttr-Related Amyloid Cardiomyopathy

Ttr-Related Cardiac Amyloidosis

Transthyretin Amyloid Cardiopathy

Transthyretin-Related Familial Amyloid Cardiomyopathy

Amyloidosis, Transthyretin-Related

AMYL-TTR

Amyloidosis I

Amyloidosis Ohio Type

Amyloidosis Type 7

Amyloidosis Vii

Amyloid Polyneuropathy

Attr

Familial Amyloid Polyneuropathy Type Ii

Hereditary Amyloidosis Transthyretin-Related

Leptomeningeal Amyloidosis

Meningocerebrovascular Amyloidosis

Oculoleptomeningeal Amyloidosis

Familial Amyloid Polyneuropathies

Amyloidosis, Leptomeningeal

Senile Cardiac Amyloidosis

Amyloid Neuropathies, Familial

Danish Type Familial Amyloid Cardiomyopathy

Familial Amyloid Neuropathy, Portuguese Type

Amyloid Polyneuropathy, Swiss Type

Hereditary Oculoleptomeningeal Amyloid Angiopathy

Amyloid Neuropathies
Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome

Crigler-Najjar Syndrome Type 1

Bilirubin Udp Glucuronyl Transferase Deficiency

Crigler Najjar Syndrome

Crigler Najjar Syndrome, Type 1

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

Bilirubin-Ugt Deficiency

Hyperbilirubinemia, Crigler-Najjar Type I

Hblrcn1

Familial Nonhemolytic Unconjugated Hyperbilirubinemia

Hereditary Unconjugated Hyperbilirubinemia

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

Bilirubin-Ugt Deficiency Type 1

Crigler-Najjar Syndrome 1

CN1

Cn-I

Crigler-Najjar Syndrome Type I

Hereditary Unconjugated Hyperbilirubinaemia

Ugt Deficiency

Bilirubin Glucuronosyltransferase Deficiency

Crigler-Najjar Disease Or Syndrome

Deficiency Of Glucuronosyltransferase

Glucuronyl Transferase Deficiency

Glucuronyltransferase Deficiency

Udp Glucuronyl Transferase Deficiency

Cns - [Crigler-Najjar Syndrome]

Congenital Familial Nonhemolytic Jaundice
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01085 ASGR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ASGR1 RGD RGD:2160
Mus musculus ASGR1 MGD MGI:88081
Bos taurus ASGR1 VGNC VGNC:26209
Macaca mulatta ASGR1 VGNC VGNC:99120
Macaca fascicularis ASGR1 NCBI NCBI:102139430
Others ASGR1 NCBI
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