GADD45B - growth arrest and DNA damage inducible beta Gene

中文名称：生长停滞和 DNA 损伤诱导β

种属: Homo sapiens

同用名: MYD118; GADD45BETA

基因 ID: 4616 | 基因类型: protein coding

关于 GADD45B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,476,127-2,478,257 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 2 paralogues. Broad expression in liver (RPKM 112.2), bone marrow (RPKM 99.7) and 23 other tissues.

功能概要

该基因是一组基因的成员，其转录水平在应激生长停滞条件和 DNA 损伤剂处理后增加。该组中的基因通过介导 p38/JNK 通路的激活来响应环境压力。这种激活是通过它们的蛋白质结合和激活 MTK1/MEKK4 激酶介导的，MTK1/MEKK4 激酶是 p38 和 JNK MAPK 的上游激活剂。这些基因或其蛋白质产物的功能涉及生长和细胞凋亡的调节。这些基因受不同机制的调控，但它们通常协同表达，并且可以协同抑制细胞生长。[RefSeq 提供，2008 年 7 月]

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and Apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GADD45B 基因产物(1)

mRNA	Protein	Name
NM_015675.4	NP_056490.2	growth arrest and DNA damage-inducible protein GADD45 beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12052864	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of JNK cascade	IDA IDA: 通过直接分析推断	9827804	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	9827804	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: 通过直接分析推断	9827804	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	9827804	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9827804	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GADD45B 蛋白结构

Ribosomal_L7Ae

0
100
160 a.a.

蛋白主名

其他名称

growth arrest and DNA damage-inducible protein GADD45 beta

myeloid differentiation primary response protein MyD118

GADD45B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GADD45B	O75293	CNOT9	Homo sapiens	Q92600-3	Validated Y2H	32296183
种属内	GADD45B	O75293	MAP3K4	Homo sapiens	Q9Y6R4	Anti Bait CoIP	16256071
种属内	GADD45B	O75293	MAP3K4	Homo sapiens	Q9Y6R4	DHFR Reconstruction	12052864
种属内	GADD45B	O75293	MAP3K4	Homo sapiens	Q9Y6R4	Anti Tag CoIP	33961781
种属内	GADD45B	O75293	MAP2K7	Homo sapiens	O14733	Solid Phase Assay	25314077
种属内	GADD45B	O75293	MAP2K7	Homo sapiens	O14733	Anti Tag CoIP	25314077
种属内	GADD45B	O75293	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GADD45B 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70212	GADD45B Protein, Human (His)	O75293 (M1-R160)	≥95%

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05230	GADD45B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	GADD45B	VGNC	VGNC:72864
Canis familiaris	GADD45B	VGNC	VGNC:41070
Bos taurus	GADD45B	VGNC	VGNC:29207
Rattus norvegicus	GADD45B	RGD	RGD:1309080
Felis catus	GADD45B	VGNC	VGNC:62432
Mus musculus	GADD45B	MGD	MGI:107776
Others	GADD45B	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GADD45B - growth arrest and DNA damage inducible beta Gene

关于 GADD45B

功能概要

GADD45B 基因产物(1)

GADD45B 蛋白结构

GADD45B 蛋白互作信息

重组 GADD45B 蛋白

关联疾病

直系同源

热门区域

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GADD45B - growth arrest and DNA damage inducible beta Gene

关于 GADD45B

功能概要

GADD45B 基因产物(1)

GADD45B 蛋白结构

GADD45B 蛋白互作信息

重组 GADD45B 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z