2. Gene
  3. NEUROG1 - neurogenin 1 Gene

NEUROG1 - neurogenin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经元 1

种属: Homo sapiens

同用名: AKA; ngn1; Math4C; bHLHa6; NEUROD3

基因 ID: 4762 | 基因类型: protein coding

关于 NEUROG1

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,534,282-135,535,964 (from NCBI)

This gene has 1 transcript (splice variant), 127 orthologues and 15 paralogues.

功能概要

启用 E-box 结合活性和蛋白质同源二聚化活性。参与多个过程，包括动物器官形态发生；颅神经发育；和硬腭形态发生。预测位于神经细胞体。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables E-box binding activity and protein homodimerization activity. Involved in several processes, including animal organ morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to be located in neuronal cell body. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NEUROG1 基因产物(1)

mRNA Protein Name
NM_006161.3 NP_006152.2 neurogenin-1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding EXP
EXP: 通过实验结果推断
20102160 GOA
enables E-box binding IDA
IDA: 通过直接分析推断
20102160 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
20102160 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
20102160 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in auditory behavior IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in cochlea development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in cochlea morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in craniofacial suture morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in genitalia development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in genitalia morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in hard palate morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in inner ear development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in inner ear morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in learned vocalization behavior IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in mastication IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in negative regulation of relaxation of muscle IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in negative regulation of saliva secretion IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in neuromuscular process controlling balance IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in peristalsis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in regulation of muscle organ development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in thorax and anterior abdomen determination IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in trigeminal nerve development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in vestibulocochlear nerve formation IGI
IGI: 通过遗传相互作用推断
23419067 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEUROG1 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (93 - 144)

  • 0
  • 100
  • 200
  • 237 a.a.
蛋白主名 其他名称

neurogenin-1

NGN-1

NEUROG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NEUROG1 Q92886 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
种属内
NEUROG1 Q92886 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
种属内
NEUROG1 Q92886 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
种属内
NEUROG1 Q92886 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
种属内
NEUROG1 Q92886 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
种属内
NEUROG1 Q92886 KLK6 Homo sapiens Q92876
Y2H Array
32814053
种属内
NEUROG1 Q92886 TCF4 Homo sapiens P15884
Anti Tag CoIP
33961781
种属内
NEUROG1 Q92886 TCF4 Homo sapiens P15884
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebellar Liponeurocytoma

Lipomatous Medulloblastoma

Central Neurocytoma
Deafness, Autosomal Dominant 52

DFNA52

Autosomal Dominant Nonsyndromic Deafness 52

Deafness, Autosomal Dominant 42

Dfna42

Autosomal Dominant Deafness 52
Cecum Carcinoma

Cecum Cancer

Caecum Carcinoma

Carcinoma Of Cecum

Cecal Cancer

Malignant Neoplasm Of Caecum

Malignant Tumor Of The Cecum
Cerebral Primitive Neuroectodermal Tumor

Pnet Of Cerebrum
Cerebellum Cancer

Cerebellar Neoplasms

Cerebellar Cancer

Malignant Tumor Of Cerebellum

Malignant Neoplasm Of Cerebellum
Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09228 NEUROG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NEUROG1 VGNC VGNC:75322
Canis familiaris NEUROG1 VGNC VGNC:43756
Bos taurus NEUROG1 VGNC VGNC:32021
Mus musculus NEUROG1 MGD MGI:107754
Rattus norvegicus NEUROG1 RGD RGD:3167
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