2. Gene
  3. CD207 - CD207 molecule Gene

CD207 - CD207 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD207 分子

种属: Homo sapiens

同用名: CLEC4K

基因 ID: 50489 | 基因类型: protein coding

关于 CD207

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,824,130-70,835,816 (from NCBI)

This gene has 1 transcript (splice variant), 877 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in skin (RPKM 26.1), esophagus (RPKM 6.2) and 1 other tissue.

功能概要

由该基因编码的蛋白质仅在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。它位于 Birbeck 颗粒中，细胞器存在于朗格汉斯细胞的细胞质中，由叠加和拉链膜组成。它是一种具有甘露糖结合特异性的 C 型凝集素，有人提出，该蛋白与甘露糖的结合导致抗原内化到 Birbeck 颗粒中，并提供非经典抗原加工途径。该基因的突变导致 Birbeck 颗粒缺乏或糖结合活性丧失。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

CD207 基因产物(1)

mRNA Protein Name
NM_015717.5 NP_056532.4 C-type lectin domain family 4 member K
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbohydrate binding IDA
IDA: 通过直接分析推断
20026605 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25910212 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IDA
IDA: 通过直接分析推断
17334373 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD207 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (213 - 321)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
蛋白主名 其他名称

C-type lectin domain family 4 member K

C-type lectin domain family 4, member K

CD207 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Array
32296183
种属内
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Prey Pooling
32296183
种属内
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Validated Y2H
25910212
种属内
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Bait-Prey Pool
25910212
种属内
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Array
25910212
种属内
CD207 Q9UJ71 CREB3 Homo sapiens O43889-2
Validated Y2H
25910212
种属内
CD207 Q9UJ71 CREB3 Homo sapiens O43889-2
Y2H Bait-Prey Pool
25910212
种属内
CD207 Q9UJ71 CREB3 Homo sapiens O43889-2
Y2H Array
25910212
种属内
CD207 Q9UJ71 ZCCHC12 Homo sapiens Q6PEW1
Y2H Prey Pooling
32296183
种属内
CD207 Q9UJ71 ZCCHC12 Homo sapiens Q6PEW1
Y2H Array
32296183
种属内
CD207 Q9UJ71 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属内
CD207 Q9UJ71 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
种属内
CD207 Q9UJ71 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD207 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7819 Langerin/CD207 Protein, Human (HEK293, His) AAH22278.1 (Y64-P328) ≥95%

CD207 抗体

目录号 产品名 应用 反应物种
HY-P81521 Langerin Antibody (YA1266) IHC-P Human

关联疾病

疾病名称 别名
Birbeck Granule Deficiency

Birbeck Granules, Absence Of

BIRGD

Absence Of Birbeck Granules
Langerhans Cell Sarcoma

Malignant Langerhans Cell Sarcoma
Histiocytosis

Chronic Histiocytosis X

Hand Schuller Christian Disease

Hand-Schüller-Christian Disease

Histiocytic Syndrome

Histiocytosis, Langerhans-Cell
Langerhans Cell Histiocytosis

Histiocytosis X

Lch

Langerhans Cell Granulomatosis

Langerhans-Cell Histiocytosis

Letterer-Siwe Disease

Hashimoto-Pritzger Disease

Histiocytosis, Langerhans-Cell

Langerhan'S Cell Histiocytosis

Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes

Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes

Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes

Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb

Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck

Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck

Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb

Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites

Letterer-Siwe Disease Involving Spleen

Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes

Letterer-Siwe Disease Of Intrapelvic Lymph Nodes

Letterer-Siwe Disease Of Intrathoracic Lymph Nodes

Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb

Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb

Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck

Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck

Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb

Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb

Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites

Letterer-Siwe Disease Of Spleen

Familial Letterer-Siwe Disease

Langerhans-Cell Histiocytosis Nos
Follicular Dendritic Cell Sarcoma

Dendritic Cell Sarcoma

Dendritic Cell Sarcoma, Follicular

Follicular Dendritic Cell Tumour

Dendritic Cell Sarcoma, Interdigitating

Dendritic Cell Sarcoma, Not Otherwise Specified
Non-Langerhans-Cell Histiocytosis

Histiocytosis, Non-Langerhans-Cell

Non-Langerhans Cell Histiocytosis
Reticulohistiocytic Granuloma

Reticulohistiocytoma

Solitary Reticulohistiocytoma

Solitary Histiocytoma

Solitary Reticulohistiocytosis
Histiocytic And Dendritic Cell Cancer

Histiocytic And Dendritic Cell
Juvenile Xanthogranuloma

Multiple Eruptive Juvenile Xanthogranuloma

Naevoxanthoendothelioma

Xanthoma Neviforme

Xanthogranuloma, Juvenile
Vulvar Proximal-Type Epithelioid Sarcoma
Central Epithelioid Sarcoma

Proximal-Type Epithelioid Sarcoma
Adult Xanthogranuloma
Interdigitating Dendritic Cell Sarcoma

Interdigitating Cell Sarcoma

Dendritic Cell Sarcoma, Interdigitating

Reticulum Cell Sarcoma
Frontal Sinus Benign Neoplasm

Neoplasm Of Frontal Sinus

Tumor Of The Frontal Sinus
Seborrheic Dermatitis

Seborrhoeic Dermatitis

Seborrhea

Seborrhoeic Eczema

Skin Seborrheic

Dermatitis, Seborrheic
Beach Ear

Acute Swimmer'S Ear

Acute Bacterial Inflammation Of External Ear

Acute Otitis Externa, Diffuse

Acute Swimmers' Ear

Tank Ear
Rhinoscleroma
Fibrosarcoma Of Bone

Malignant Histiocytosis

Malignant Fibroxanthoma

Malignant Fibrous Histiocytoma

Histiocytic Medullary Reticulosis

Nasal Type Extranodal Nk/T-Cell Lymphoma

Histiocytic Sarcoma
Cavernous Sinus Meningioma

Meningioma Of The Cavernous Sinus
Otorrhea

Discharging Ear
Malignant Histiocytic Disease

Histiocytic Disorders, Malignant
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02208 CD207 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CD207 VGNC VGNC:27011
Rattus norvegicus CD207 RGD RGD:1565913
Felis catus CD207 VGNC VGNC:60596
Mus musculus CD207 MGD MGI:2180021
Canis familiaris CD207 VGNC VGNC:54285
Macaca mulatta CD207 VGNC VGNC:70818
Others CD207 NCBI
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