2. Gene
  3. PDK1 - pyruvate dehydrogenase kinase 1 Gene

PDK1 - pyruvate dehydrogenase kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丙酮酸脱氢酶激酶 1

种属: Homo sapiens

基因 ID: 5163 | 基因类型: protein coding

关于 PDK1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:172,555,373-172,724,312 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 4.7), adrenal (RPKM 4.3) and 25 other tissues.

功能概要

丙酮酸脱氢酶 (PDH) 是一种线粒体多酶复合物，可催化丙酮酸的氧化脱羧作用，是负责调节哺乳动物碳水化合物燃料稳态的主要酶之一。酶活性受磷酸化/去磷酸化循环的调节。特定丙酮酸脱氢酶激酶 (PDK) 对 PDH 的磷酸化导致失活。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2013 年 6 月]

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major Enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

PDK1 基因产物(36)

mRNA Protein Name
XR_427093.4
XM_047444740.1 XP_047300696.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X7
XR_007076392.1
XR_007076402.1
NR_103729.2
XR_001738771.2
XR_922944.3
XR_007076401.1
XR_007076399.1
XR_922945.1
XR_007076391.1
XR_007076400.1
XR_007076403.1
XM_006712594.3 XP_006712657.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X6
XR_922942.2
XR_007076393.1
XM_047444736.1 XP_047300692.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XM_011511344.3 XP_011509646.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XR_007076398.1
XM_047444739.1 XP_047300695.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X5
XR_001738775.3
XR_922943.2
XR_007076394.1
XM_011511347.3 XP_011509649.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XM_047444737.1 XP_047300693.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X3
XM_011511345.4 XP_011509647.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XR_007076395.1
XR_001738774.3
XR_001738772.3
XR_007076396.1
XR_007076397.1
NR_103731.1
NM_001278549.2 NP_001265478.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor
XM_047444738.1 XP_047300694.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X4
NM_002610.5 NP_002601.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2 precursor
XM_011511343.3 XP_011509645.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7782287 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
17683942 GOA
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA
IDA: 通过直接分析推断
7499431 GOA
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
IMP: 通过突变表型推断
22195962 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell population proliferation IMP
IMP: 通过突变表型推断
18541534 GOA
involved in hypoxia-inducible factor-1alpha signaling pathway IMP
IMP: 通过突变表型推断
21763680 GOA
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: 通过突变表型推断
18541534 GOA
involved in regulation of glucose metabolic process IMP
IMP: 通过突变表型推断
18541534 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDK1 蛋白结构

BCDHK_Adom3

BCDHK_Adom3: Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (56 - 220)

HATPase_c

HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (269 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
蛋白主名 其他名称

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

PDH kinase 1

mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1

pyruvate dehydrogenase kinase, isoenzyme 1

PDK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PDK1 Q15118 PKN2 Homo sapiens Q16513
Protein Kinase Assay
17110931
Intra PDK1 Q15118 PDHA1 Homo sapiens P08559
Enzymatic Study
7782287
Intra PDK1 Q15118 PDHA1 Homo sapiens P08559
BioID
29568061
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73718 PDK1 Protein, Human (sf9, His) Q15118 (S29-A436) ≥95%

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0645 Dicoumarol Inhibitor 99.59% 否
HY-124060 PS423 / 否
Pre-clinical Phase
生物活性分子 (40)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10514 BX795 99.84% 否
HY-14981 GSK2334470 Inhibitor 99.78% 否
HY-121744 PS10 Inhibitor 99.01% 否
HY-N0047 Polyphyllin I 99.89% 否
HY-19564 JX06 99.78% 否
HY-12492 VER-246608 Inhibitor 98.92% 否
HY-11005 BX-912 99.13% 否
HY-15967 PS48 Activator 99.71% 否
HY-124379 TPCK 98.55% 否
HY-N6769 Radicicol Inhibitor 99.63% 否
HY-10547 OSU-03012 98.88% 否
HY-14440 MP7 Inhibitor 99.67% 否
HY-121629 PS210 Activator 98.30% 否
HY-15569 NU6102 Inhibitor 99.23% 否
HY-13842 BX517 Inhibitor ≥98.0% 否
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% 否
HY-114645 PDK1-IN-RS2 Inhibitor 98.50% 否
HY-13856 (R)-PS210 Inhibitor 98.09% 否
HY-149814 PDK-IN-1 Inhibitor 99.74% 否
HY-157299 PDK-IN-3 Inhibitor 99.87% 否
HY-10515 BX-320 Inhibitor 99.4% 否
HY-13851 PS47 98.83% 否
HY-129426 PDK1/Akt/Flt dual pathway inhibitor Inhibitor / 否
HY-117809 PDK1-IN-2 Inhibitor 98.90% 否
HY-151465 HIF-1α-IN-4 Inhibitor 99.95% 否
HY-151466 HIF-1α-IN-5 Inhibitor 99.95% 否
HY-156375 PKM2 activator 6 / 否
HY-W070306 PDK1-IN-1 Inhibitor 99.95% 否
HY-W998345 SMART1 Inhibitor / 否
HY-135773 CRTh2 antagonist 3 / 否
HY-13844 PDK1-IN-3 Inhibitor / 否
HY-149275 PKM2/PDK1-IN-1 / 否
HY-156109 PDK-IN-2 / 否
HY-P5450 PDKtide / 否
HY-RS10273 PDK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10274 Pdk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10275 Pdk1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117885 PF-5177624 Inhibitor / 否
HY-124288 PDK1/AurA-IN-1 / 否
HY-W837864 PDK1 allosteric modulator 1 / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PDK1 VGNC VGNC:97211
Rattus norvegicus PDK1 RGD RGD:69427
Felis catus PDK1 VGNC VGNC:68775
Bos taurus PDK1 VGNC VGNC:32703
Macaca mulatta PDK1 VGNC VGNC:75932
Mus musculus PDK1 MGD MGI:1926119
Others PDK1 NCBI
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