2. Gene
  3. PPIL1 - peptidylprolyl isomerase like 1 Gene

PPIL1 - peptidylprolyl isomerase like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肽基脯氨酰异构酶 1

种属: Homo sapiens

同用名: CYPL1; PCH14; hCyPX; PPIase; CGI-124

基因 ID: 51645 | 基因类型: protein coding

关于 PPIL1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:36,854,829-36,874,803 (from NCBI)

This gene has 2 transcripts (splice variants), 215 orthologues, 22 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 23.5), thyroid (RPKM 20.4) and 25 other tissues.

功能概要

该基因是肽基脯氨酰异构酶 (PPIases) 亲环蛋白家族的成员。亲环蛋白是一个高度保守、普遍存在的家族，其成员在蛋白质折叠、环孢菌素 A 的免疫抑制和 HIV-1 病毒颗粒的感染中起重要作用。基于与其他 PPIases 的相似性，该蛋白质可以加速蛋白质的折叠，并可能催化寡肽中脯氨酸亚胺肽键的顺反异构化。[RefSeq 提供，2008 年 7 月]

This gene is a member of the Cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and Infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

PPIL1 基因产物(1)

mRNA Protein Name
NM_016059.5 NP_057143.1 peptidyl-prolyl cis-trans isomerase-like 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables disordered domain specific binding IPI
IPI: 通过物理相互作用推断
20007319 GOA
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: 通过直接分析推断
16595688 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16595688 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in embryonic brain development IMP
IMP: 通过突变表型推断
33220177 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
involved in mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
33220177 GOA
involved in protein peptidyl-prolyl isomerization IDA
IDA: 通过直接分析推断
16595688 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in nucleus IDA
IDA: 通过直接分析推断
28076346 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPIL1 蛋白结构

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (15 - 162)

  • 0
  • 100
  • 166 a.a.
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase-like 1

cyclophilin like 1

重组 PPIL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71226 PPIL1 Protein, Human (His) Q9Y3C6 (M1-G166) ≥95%

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 14

PCH14

Pontocerebellar Hypoplasia Type 14

Pontocerebellar Hypoplasia 14

Doid:0112325
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Spastic Quadriplegia

Spastic Quadriplegic Cerebral Palsy

Quadriplegic Infantile Cerebral Palsy

Tetraplegic Infantile Cerebral Palsy

Cerebral Palsy Spastic Quadriplegic

Quadriplegic Cerebral Palsy

Spastic Quadriplegia Cerebral Palsy

Spastic Tetraplegia Cerebral Palsy

Cerebral Palsy, Quadriplegic, Infantile

Cerebral Palsy With Spastic Tetraplegia

Congenital Spastic Quadriplegia

Spastic Tetraplegic Cerebral Palsy

Congenital Quadriplegia Nos

Tetraplegic Cerebral Palsy
Quadriplegia

Tetraplegia

Tetraplegias
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10954 PPIL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PPIL1 VGNC VGNC:102486
Rattus norvegicus PPIL1 RGD RGD:1309119
Bos taurus PPIL1 VGNC VGNC:33201
Mus musculus PPIL1 MGD MGI:1916066
Macaca mulatta PPIL1 VGNC VGNC:104420
Canis familiaris PPIL1 VGNC VGNC:44855
Others PPIL1 NCBI
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