2. Gene
  3. Crk - CRK proto-oncogene, adaptor protein Gene

Crk - CRK proto-oncogene, adaptor protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Crko; CrkII

基因 ID: 54245 | 基因类型: protein coding

关于 Crk

功能概要

Enables several functions, including insulin-like growth factor receptor binding activity; protein tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to nitric oxide; and response to peptide hormone. Located in membrane raft. Biomarker of degenerative disc disease. Orthologous to human CRK (CRK proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Crk 基因产物(1)

mRNA Protein Name
NM_019302.1 NP_062175.1 adapter molecule crk
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytoskeletal protein binding IPI
IPI: 通过物理相互作用推断
17615370 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
9348226 RGD
enables insulin-like growth factor receptor binding IPI
IPI: 通过物理相互作用推断
12837295 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8940134 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
12011056 RGD
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
16187300 RGD
enables protein-macromolecule adaptor activity IMP
IMP: 通过突变表型推断
8901553 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
20623582 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to endothelin IPI
IPI: 通过物理相互作用推断
12719447 RGD
involved in cellular response to insulin-like growth factor stimulus IPI
IPI: 通过物理相互作用推断
12837295 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: 通过直接分析推断
15128873 RGD
involved in cellular response to nitric oxide IPI
IPI: 通过物理相互作用推断
12714323 RGD
involved in cellular response to transforming growth factor beta stimulus IPI
IPI: 通过物理相互作用推断
12837295 RGD
involved in negative regulation of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
18835194 RGD
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
12198159 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
12714323 RGD
involved in protein localization to membrane IMP
IMP: 通过突变表型推断
12198159 RGD
involved in regulation of Rac protein signal transduction IMP
IMP: 通过突变表型推断
12198159 RGD
involved in response to cholecystokinin IDA
IDA: 通过直接分析推断
14622258 RGD
involved in response to hepatocyte growth factor IPI
IPI: 通过物理相互作用推断
16187300 RGD
involved in response to hydrogen peroxide IPI
IPI: 通过物理相互作用推断
16187300 RGD
involved in response to peptide IPI
IPI: 通过物理相互作用推断
14622258 RGD
involved in response to yeast IEP
IEP: 通过表达模式推断
19958054 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

adapter molecule crk

avian sarcoma virus CT10 (v-crk) oncogene homolog

p38

proto-oncogene C-crk

v-crk avian sarcoma virus CT10 oncogene homolog

v-crk sarcoma virus CT10 oncogene homolog

Crk 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Crk Q63768 PTPN1 Homo sapiens P18031
Pull Down
12023880
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-112622 GSK3186899 Inhibitor 98.61% Phase 1
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112346 RGB-286147 98.60% 否
HY-RS16222 Crk Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-143322 CRK12-IN-2 Inhibitor / 否
HY-145812 CRK12-IN-1 Inhibitor / 否
HY-RS03184 CRK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Crk NCBI NCBI:1398
Mus musculus Crk NCBI NCBI:12928
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