YY1AP1 - YY1 associated protein 1 Gene

中文名称：YY1 相关蛋白 1

种属: Homo sapiens

同用名: GRNG; HCCA1; HCCA2; YY1AP

基因 ID: 55249 | 基因类型: protein coding

关于 YY1AP1

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,659,442-155,688,996 (from NCBI)

This gene has 25 transcripts (splice variants), 156 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 35.6), bone marrow (RPKM 27.3) and 25 other tissues.

功能概要

编码的基因产物可能与 YY1 蛋白相互作用；然而，其确切功能尚不清楚。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

YY1AP1 基因产物(12)

mRNA	Protein	Name
NM_001198899.2	NP_001185828.1	YY1-associated protein 1 isoform 1
NM_001198900.2	NP_001185829.1	YY1-associated protein 1 isoform 1
NM_001198901.2	NP_001185830.1	YY1-associated protein 1 isoform 3
NM_001198902.2	NP_001185831.1	YY1-associated protein 1 isoform 3
NM_001198903.1	NP_001185832.1	YY1-associated protein 1 isoform 6
NM_001198904.1	NP_001185833.1	YY1-associated protein 1 isoform 7
NM_001198905.2	NP_001185834.1	YY1-associated protein 1 isoform 8
NM_001198906.2	NP_001185835.1	YY1-associated protein 1 isoform 9
NM_018253.4	NP_060723.2	YY1-associated protein 1 isoform 1
NM_139118.3	NP_620829.1	YY1-associated protein 1 isoform 2
NM_139119.3	NP_620830.1	YY1-associated protein 1 isoform 3
NM_139121.3	NP_620832.1	YY1-associated protein 1 isoform 5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14744866	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell differentiation	IMP IMP: 通过突变表型推断	27939641	GOA
involved in cell population proliferation	IMP IMP: 通过突变表型推断	27939641	GOA
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	17541814	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	27939641	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Ino80 complex	IDA IDA: 通过直接分析推断	27939641	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	27939641	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	27939641	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17541814	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

YY1-associated protein 1

hepatocellular carcinoma susceptibility protein

YY1AP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	YY1AP1	Q9H869	YY1	Homo sapiens	P25490	Confocal	27939641
种属内	YY1AP1	Q9H869	YY1	Homo sapiens	P25490	Anti Bait CoIP	27939641
种属内	YY1AP1	Q9H869	ATXN1	Homo sapiens	P54253	Y2H	16713569

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Grange Syndrome

Arterial Occlusive Disease, Progressive, With Hypertension, Heart Defects, Bone Fragility, And Brachysyndactyly	Grange Occlusive Arterial Syndrome
GRNG	Progressive Arterial Occlusive Disease-Hypertension-Heart Defects-Bone Fragility-Brachysyndactyly Syndrome

Fibromuscular Dysplasia

Brachydactyly

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Chromosome 2q35 Duplication Syndrome

Syndactyly	Syndactyly Type 1
Sdty1	Zygodactyly
Syndactyly, Type I	Sd1
Syndactyly, Type 1, With Or Without Craniosynostosis	Symphalangism
Non-Syndromic Syndactyly	Symphalangy
Webbing Of Digits	Syndactyly, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15947	YY1AP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	YY1AP1	MGD	MGI:1917579
Macaca mulatta	YY1AP1	VGNC	VGNC:78428

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