ZCCHC8 - zinc finger CCHC-type containing 8 Gene

中文名称：含锌指 CCHC 型 8

种属: Homo sapiens

同用名: PFBMFT5

基因 ID: 55596 | 基因类型: protein coding

关于 ZCCHC8

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,471,600-122,500,932 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and is associated with 60 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.2), testis (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码一种支架蛋白，作为核 RNA 外泌体复合物的评估因子。编码的蛋白质与 hMTR4 和 RNA 结合因子 RBM7 一起形成三聚体人核外泌体靶向 (NEXT) 复合物，后者促进非编码启动子上游转录本、增强子 RNA 和组蛋白 3'- 延伸产物的外泌体降解。和小核 RNA 转录。这种复合物也被认为通过与外泌体和剪接体的相互作用募集外泌体来降解内含子 RNA。它包含一个 N 末端锌关节结构域和一个 C 末端富含脯氨酸的结构域。[RefSeq 提供，2017 年 4 月]

This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]

ZCCHC8 基因产物(5)

mRNA	Protein	Name
NM_001350935.2	NP_001337864.1	zinc finger CCHC domain-containing protein 8 isoform 2
NM_001350936.2	NP_001337865.1	zinc finger CCHC domain-containing protein 8 isoform 3
NM_001350937.2	NP_001337866.1	zinc finger CCHC domain-containing protein 8 isoform 4
NM_001350938.2	NP_001337867.1	zinc finger CCHC domain-containing protein 8 isoform 4
NM_017612.5	NP_060082.2	zinc finger CCHC domain-containing protein 8 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	31488579	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16263084	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RNA processing	IMP IMP: 通过突变表型推断	31488579	GOA
involved in mRNA 3'-end processing	IMP IMP: 通过突变表型推断	31488579	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of TRAMP complex	IDA IDA: 通过直接分析推断	21855801	GOA
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
NOT located in nucleolus	IDA IDA: 通过直接分析推断	21855801	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	16263084	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21855801	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZCCHC8 蛋白结构

zf-CCHC

PSP

0
200
400
600
707 a.a.

蛋白主名

其他名称

zinc finger CCHC domain-containing protein 8

TRAMP-like complex RNA-binding factor ZCCHC8

ZCCHC8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZCCHC8	Q6NZY4	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	17525332
种属内	ZCCHC8	Q6NZY4	RBM7	Homo sapiens	Q9Y580	X-Ray Diffraction	27905398
种属内	ZCCHC8	Q6NZY4	RBM7	Homo sapiens	Q9Y580	MST	27905398
种属内	ZCCHC8	Q6NZY4	RBM7	Homo sapiens	Q9Y580	Anti Tag CoIP	27905398
种属内	ZCCHC8	Q6NZY4	RBM7	Homo sapiens	Q9Y580	Pull Down	27905398
种属内	ZCCHC8	Q6NZY4	RBM7	Homo sapiens	Q9Y580	Enzymatic Footprint	27905398

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 5

PFBMFT5

Pulmonary Fibrosis, And/Or Bone Marrow Failure, Telomere-Related, 5

Gliofibroma

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome	Syndromic Diarrhea
Tricho-Hepato-Enteric Syndrome	Sd/The
Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome	THES1
Phenotypic Diarrhea	Thes
Phenotypic Diarrhea Of Infancy	Diarrhea, Syndromic
Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa	Intractable Diarrhea With Phenotypic Anomalies
Syndromatic Diarrhea	Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Pulmonary Fibrosis

Fibrosis Of Lung

Trichohepatoenteric Syndrome 2

THES2

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1	PCH1E
Norman Disease	Pch1
Pontocerebellar Hypoplasia With Anterior Horn Cell Disease	Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy
Pontocerebellar Hypoplasia Type 1e	Pontocerebellar Hypoplasia 1e
Doid:0112322	Doid:0112330

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Pontocerebellar Hypoplasia

Pch	Congenital Pontocerebellar Hypoplasia
Opch	Hypoplasia, Pontocerebellar
Pontoneocerebellar Hypoplasia	Nonsyndromic Pontocerebellar Hypoplasia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16007	ZCCHC8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ZCCHC8	VGNC	VGNC:48572
Rattus norvegicus	ZCCHC8	RGD	RGD:1309774
Felis catus	ZCCHC8	VGNC	VGNC:67198
Bos taurus	ZCCHC8	VGNC	VGNC:37123
Macaca mulatta	ZCCHC8	VGNC	VGNC:79487
Mus musculus	ZCCHC8	MGD	MGI:1917900

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ZCCHC8 - zinc finger CCHC-type containing 8 Gene

关于 ZCCHC8

功能概要

ZCCHC8 基因产物(5)

ZCCHC8 蛋白结构

ZCCHC8 蛋白互作信息

关联疾病

直系同源

热门区域

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ZCCHC8 - zinc finger CCHC-type containing 8 Gene

关于 ZCCHC8

功能概要

ZCCHC8 基因产物(5)

ZCCHC8 蛋白结构

ZCCHC8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z