PCID2 - PCI domain containing 2 Gene

中文名称：含 PCI 结构域 2

种属: Homo sapiens

同用名: F10

基因 ID: 55795 | 基因类型: protein coding

关于 PCID2

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,165,002-113,208,669 (from NCBI)

This gene has 16 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 6.6), ovary (RPKM 4.5) and 25 other tissues.

功能概要

该基因编码 TREX-2 复合物 (转录和输出复合物 2) 的一个成分，它调节 mRNA 从细胞核的输出。该蛋白调节 Mad2 有丝分裂停滞缺陷样蛋白 1 的表达，这是一种细胞分裂检查点蛋白。这种蛋白质还与 Brca2 (乳腺癌 2) 蛋白质相互作用并使其稳定。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast Cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

PCID2 基因产物(14)

mRNA	Protein	Name
NM_001127202.4	NP_001120674.1	PCI domain-containing protein 2 isoform 1
NM_001127203.4	NP_001120675.1	PCI domain-containing protein 2 isoform 1
NM_001258213.3	NP_001245142.1	PCI domain-containing protein 2 isoform 3
NM_001320655.2	NP_001307584.1	PCI domain-containing protein 2 isoform 3
NM_001320656.2	NP_001307585.1	PCI domain-containing protein 2 isoform 2
NM_001320657.2	NP_001307586.1	PCI domain-containing protein 2 isoform 4
NM_001320659.2	NP_001307588.1	PCI domain-containing protein 2 isoform 5
NM_001320660.2	NP_001307589.1	PCI domain-containing protein 2 isoform 6
NM_001353091.2	NP_001340020.1	PCI domain-containing protein 2 isoform 7
NM_001353092.2	NP_001340021.1	PCI domain-containing protein 2 isoform 3
NM_001353093.2	NP_001340022.1	PCI domain-containing protein 2 isoform 7
NM_001353094.2	NP_001340023.1	PCI domain-containing protein 2 isoform 7
NM_001353095.2	NP_001340024.1	PCI domain-containing protein 2 isoform 8
NM_018386.5	NP_060856.2	PCI domain-containing protein 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	22343721	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	20870947	GOA
involved in negative regulation of cysteine-type endopeptidase activity	IMP IMP: 通过突变表型推断	20870947	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	20870947	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: 通过突变表型推断	20870947	GOA
involved in regulation of mRNA stability	IMP IMP: 通过突变表型推断	20870947	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	23591820	GOA
part of nuclear pore nuclear basket	IDA IDA: 通过直接分析推断	23591820	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23591820	GOA
part of transcription export complex 2	IDA IDA: 通过直接分析推断	23591820	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCID2 蛋白结构

PCI

0
100
200
300
399 a.a.

蛋白主名

其他名称

PCI domain-containing protein 2

CSN12-like protein

PCID2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PCID2	Q5JVF3	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
种属内	PCID2	Q5JVF3	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956
种属内	PCID2	Q5JVF3	SEM1	Homo sapiens	P60896	Y2H Prey Pooling	32296183
种属内	PCID2	Q5JVF3	SEM1	Homo sapiens	P60896	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10150	PCID2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PCID2	VGNC	VGNC:44305
Mus musculus	PCID2	MGD	MGI:2443003
Felis catus	PCID2	VGNC	VGNC:64069
Macaca mulatta	PCID2	VGNC	VGNC:75680
Rattus norvegicus	PCID2	RGD	RGD:1307041
Bos taurus	PCID2	VGNC	VGNC:32629

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