Becn1 - beclin 1, autophagy related Gene

中文名称：beclin 1 ，自噬相关

种属: Mus musculus

同用名: Atg6

关于 Becn1

功能概要

实现相同的蛋白质结合活性。参与多个过程，包括线粒体的自噬；细胞对葡萄糖饥饿的反应；和凋亡细胞的吞噬。作用于多个过程的上游或内部，包括 β 淀粉样蛋白代谢过程；自噬体组装的负调控；和心肌肥厚的正调节作用。位于自噬体；吞噬泡;和跨高尔基网络。磷脂酰肌醇 3-激酶复合物的一部分，III 类。在中枢神经系统中表达；胚外内脏内胚层；感觉器官；和脾脏。用于研究系统性红斑狼疮。该基因的人类直系同源物与马查多-约瑟夫病有关。与人类 BECN1 (beclin 1) 同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Involved in several processes, including Autophagy of mitochondrion; cellular response to glucose starvation; and engulfment of apoptotic cell. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of autophagosome assembly; and positive regulation of cardiac muscle hypertrophy. Located in autophagosome; phagocytic vesicle; and trans-Golgi network. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; extraembryonic visceral endoderm; sensory organ; and spleen. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]