2. Gene
  3. Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷脂酰肌醇 3-激酶催化亚基 3 型

种属: Mus musculus

同用名: Vps34; 5330434F23Rik

基因 ID: 225326 | 基因类型: protein coding

关于 Pik3c3

Chromosome 18: 30,405,800-30,481,179 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 19 phenotypes. Broad expression in CNS E14 (RPKM 15.), CNS E18 (RPKM 11.) and 24 other tissues.

功能概要

该基因编码的蛋白可启动蛋白激酶活性。参与细胞对葡萄糖饥饿和巨自噬的反应。作用于多个过程的上游或内部，包括细胞对饥饿的反应；磷脂酰肌醇-3-磷酸生物合成过程；和蛋白质定位到吞噬细胞组装位点。位于吞噬泡内。磷脂酰肌醇 3-激酶复合物的一部分，III 类。在 Meckel 的软骨中表达；心血管系统;肢;和骨架。与人 PIK3C3（磷脂酰肌醇 3-激酶催化亚基 3 型）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity. Involved in cellular response to glucose starvation and macroautophagy. Acts upstream of or within several processes, including cellular response to starvation; phosphatidylinositol-3-phosphate biosynthetic process; and protein localization to phagophore assembly site. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 基因产物(1)

mRNA Protein Name
NM_181414.6 NP_852079.2 phosphatidylinositol 3-kinase catalytic subunit type 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22493499 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
15010863 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within autophagosome assembly IMP
IMP: 通过突变表型推断
24098492 MGI
involved in cellular response to glucose starvation IDA
IDA: 通过直接分析推断
23332761 MGI
acts upstream of or within cellular response to starvation IMP
IMP: 通过突变表型推断
24098492 MGI
involved in macroautophagy IMP
IMP: 通过突变表型推断
23332761 MGI
acts upstream of or within phosphatidylinositol-3-phosphate biosynthetic process IMP
IMP: 通过突变表型推断
24098492 MGI
acts upstream of or within protein localization to phagophore assembly site IMP
IMP: 通过突变表型推断
24098492 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
15010863 MGI
involved in synaptic vesicle endocytosis EXP
EXP: 通过实验结果推断
35318705 MGI
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
35318705 MGI
involved in synaptic vesicle endocytosis IEP
IEP: 通过表达模式推断
35318705 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
35318705 MGI
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
35318705 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
35318705 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
35318705 MGI
located in phagocytic vesicle IDA
IDA: 通过直接分析推断
22493499 MGI
part of phosphatidylinositol 3-kinase complex, class III IDA
IDA: 通过直接分析推断
23332761 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
20955765 MGI
is active in postsynapse IMP
IMP: 通过突变表型推断
20955765 MGI
is active in postsynaptic endosome IDA
IDA: 通过直接分析推断
35318705 MGI
is active in postsynaptic endosome IMP
IMP: 通过突变表型推断
35318705 MGI
is active in presynaptic endosome IDA
IDA: 通过直接分析推断
35318705 MGI
is active in presynaptic endosome IMP
IMP: 通过突变表型推断
35318705 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pik3c3 蛋白结构

C2_PI3K_class_III

C2_PI3K_class_III: cd08397 (25 - 185)

PI3Ka_III

PI3Ka_III: cd00870 (282 - 502)

PI3Kc_III

PI3Kc_III: cd00896 (538 - 882)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
蛋白主名 其他名称

phosphatidylinositol 3-kinase catalytic subunit type 3

PI3-kinase type 3

PI3K type 3

phosphoinositide-3-kinase, class 3

ptdIns-3-kinase type 3

Pik3c3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Pik3c3 Q6PF93 Becn1 Mus musculus O88597
Anti Bait CoIP
23332761
种属内
Pik3c3 Q6PF93 Becn1 Mus musculus O88597
Anti Bait CoIP
23974797
种属内
Pik3c3 Q6PF93 Becn1 Mus musculus O88597
Anti Bait CoIP
24849286
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12481 SAR405 Inhibitor 99.74% 否
HY-137506 XST-14 99.26% 否
HY-12481A SAR405 R enantiomer 99.94% 否
HY-RS10520 PIK3C3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10521 Pik3c3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10522 Pik3c3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pik3c3 NCBI NCBI:5289
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