2. Gene
  3. Ptafr - platelet-activating factor receptor Gene

Ptafr - platelet-activating factor receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：血小板活化因子受体

种属: Rattus norvegicus

基因 ID: 58949 | 基因类型: protein coding

关于 Ptafr

Primary_assembly 5: 144,765,976-144,795,251 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 223 orthologues, 6 paralogues and is associated with 21 phenotypes. Biased expression in Spleen (RPKM 63.9), Lung (RPKM 25.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动有丝分裂原活化蛋白激酶结合活性和血小板活化因子受体活性。参与多个过程，包括基因表达的正调控；运输的积极监管；和细胞外渗的调节。位于质膜。用于研究多种疾病，包括急性肾功能衰竭；中性粒细胞减少症;围产期坏死性小肠结肠炎；胸膜炎;和短暂性脑缺血。结膜炎的生物标志物；坐骨神经病;和短暂性脑缺血。与人 PTAFR（血小板活化因子受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables mitogen-activated protein kinase binding activity and platelet activating factor receptor activity. Involved in several processes, including positive regulation of gene expression; positive regulation of transport; and regulation of cellular extravasation. Located in plasma membrane. Used to study several diseases, including acute kidney failure; neutropenia; perinatal necrotizing enterocolitis; pleurisy; and transient cerebral ischemia. Biomarker of conjunctivitis; sciatic neuropathy; and transient cerebral ischemia. Orthologous to human PTAFR (platelet activating factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ptafr 基因产物(1)

mRNA Protein Name
NM_053321.2 NP_445773.1 platelet-activating factor receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mitogen-activated protein kinase binding IDA
IDA: 通过直接分析推断
23911909 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
23911909 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9495811 RGD
involved in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
IEP: 通过表达模式推断
9321918 RGD
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
2170386 RGD
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
17515866 RGD
involved in cellular response to gravity IEP
IEP: 通过表达模式推断
15659787 RGD
involved in negative regulation of blood pressure IMP
IMP: 通过突变表型推断
3019921 RGD
involved in parturition IMP
IMP: 通过突变表型推断
1849751 RGD
involved in positive regulation of cellular extravasation IMP
IMP: 通过突变表型推断
2829894 RGD
involved in positive regulation of gastro-intestinal system smooth muscle contraction IMP
IMP: 通过突变表型推断
10821044 RGD
involved in positive regulation of inositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
8798508 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
11779582 RGD
involved in positive regulation of leukocyte cell-cell adhesion IMP
IMP: 通过突变表型推断
8592427 RGD
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: 通过突变表型推断
10528212 RGD
involved in positive regulation of maternal process involved in parturition IMP
IMP: 通过突变表型推断
1849751 RGD
involved in positive regulation of neutrophil degranulation IMP
IMP: 通过突变表型推断
2829894 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
8216700 RGD
involved in positive regulation of smooth muscle contraction IMP
IMP: 通过突变表型推断
10821044 RGD
involved in positive regulation of transcytosis IMP
IMP: 通过突变表型推断
9664076 RGD
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
8216700 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
2545780 RGD
involved in positive regulation of voltage-gated chloride channel activity IDA
IDA: 通过直接分析推断
8168510 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
10482285 RGD
involved in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
IEP: 通过表达模式推断
9065783 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
10447766 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
9065783 RGD
involved in response to organophosphorus IEP
IEP: 通过表达模式推断
9321918 RGD
involved in response to symbiotic bacterium IEP
IEP: 通过表达模式推断
10447766 RGD
involved in transcytosis IMP
IMP: 通过突变表型推断
9664076 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

platelet-activating factor receptor

PAF-R

PAFr

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11347 PTAFR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11348 Ptafr Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11349 Ptafr Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptafr NCBI NCBI:5724
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