SPANXC - SPANX family member C Gene

中文名称：SPANX 家族成员 C

种属: Homo sapiens

同用名: CTp11; CT11.3; SPANXE; SPANX-C; SPANX-E

关于 SPANXC

功能概要

几个睾丸特异性基因的时间调节转录和翻译需要在雄性生殖细胞谱系中启动成熟精子形成所必需的一系列分子和形态学变化。该基因是 SPANX 家族的成员，位于 X 染色体上的基因簇中。SPANX 基因编码差异表达的睾丸特异性蛋白质，这些蛋白质定位于各种亚细胞区室。这种特殊的基因编码一种定位于细胞核的蛋白质，并在高度转移的细胞系中表达，使该蛋白质成为潜在的诊断和预后标志物。该蛋白属于癌症/睾丸抗原家族，代表了癌症免疫治疗的潜在靶点。[RefSeq 提供，2008 年 7 月]

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of Cancer/testis antigens and represents a potential target for Cancer Immunotherapy. [provided by RefSeq, Jul 2008]