1. Gene
  2. UNKL - unk like zinc finger Gene

UNKL - unk like zinc finger Gene

中文名称:unk 样锌指蛋白

种属: Homo sapiens

同用名: ZC3H5L; C16orf28; ZC3HDC5L

基因 ID: 64718 | 基因类型: protein coding

关于 UNKL

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,363,205-1,414,704 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 4.2) and 25 other tissues.

功能概要

该基因编码可能在 Rac 信号传导中起作用的无名指蛋白。它可以与 Brg/Brm 相关因子 60b 结合并促进其泛素化。该基因的可变剪接导致多个转录变体。[RefSeq 提供,2013 年 6 月]

This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

UNKL 基因产物(7)

mRNA Protein Name
NM_001037125.4 NP_001032202.1 putative E3 ubiquitin-protein ligase UNKL isoform 2
NM_001193388.4 NP_001180317.2 putative E3 ubiquitin-protein ligase UNKL isoform 1
NM_001193389.2 NP_001180318.1 putative E3 ubiquitin-protein ligase UNKL isoform 4
NM_001276414.2 NP_001263343.1 putative E3 ubiquitin-protein ligase UNKL isoform 5
NM_001367622.1 NP_001354551.1 putative E3 ubiquitin-protein ligase UNKL isoform 3
NM_001370526.1 NP_001357455.1 putative E3 ubiquitin-protein ligase UNKL isoform 6
NM_001372107.1 NP_001359036.1 putative E3 ubiquitin-protein ligase UNKL isoform 7
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20148946 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UNKL 蛋白结构

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (292 - 308)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (637 - 675)

  • 0
  • 200
  • 400
  • 600
  • 680 a.a.
蛋白主名 其他名称

putative E3 ubiquitin-protein ligase UNKL

RING finger protein unkempt-like

UNKL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UNKL Q9H9P5 SMARCD2 Homo sapiens Q92925 20148946
种属内
UNKL Q9H9P5 RAC1 Homo sapiens P63000
Y2H
20148946
种属内
UNKL Q9H9P5 RAC1 Homo sapiens P63000 20148946
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UNKL RGD RGD:1565247
Canis familiaris UNKL VGNC VGNC:54086
Mus musculus UNKL MGD MGI:1921404
Bos taurus UNKL VGNC VGNC:58618
Macaca mulatta UNKL VGNC VGNC:99625
Felis catus UNKL VGNC VGNC:66838