2. Gene
  3. STK4 - serine/threonine kinase 4 Gene

STK4 - serine/threonine kinase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝氨酸/苏氨酸激酶 4

种属: Homo sapiens

同用名: KRS2; MST1; YSK3

基因 ID: 6789 | 基因类型: protein coding

关于 STK4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,966,512-45,080,021 (from NCBI)

This gene has 17 transcripts (splice variants), 130 orthologues, 35 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种细胞质激酶，其结构类似于酵母 Ste20p 激酶，后者作用于应激诱导的丝裂原活化蛋白激酶级联反应的上游。编码的蛋白可以磷酸化髓鞘碱性蛋白并发生自身磷酸化。编码蛋白的半胱天冬酶切割片段已显示能够磷酸化组蛋白 H2B。这种蛋白质催化的特定磷酸化与细胞凋亡相关，并且这种蛋白质可能诱导在此过程中观察到的染色质浓缩。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with Apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

STK4 基因产物(2)

mRNA Protein Name
NM_001352385.2 NP_001339314.1 serine/threonine-protein kinase 4 isoform 2
NM_006282.5 NP_006273.1 serine/threonine-protein kinase 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
8566796 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
16751106 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8702870 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
8566796 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14729613 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
11805089 GOA
enables protein kinase activity IGI
IGI: 通过遗传相互作用推断
19962960 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
9545236 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
8566796 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic process IDA
IDA: 通过直接分析推断
21212262 GOA
acts upstream of or within cell morphogenesis IDA
IDA: 通过直接分析推断
11805089 GOA
involved in hippo signaling IDA
IDA: 通过直接分析推断
20412773 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
8566796 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
20412773 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
16751106 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
15109305 GOA
acts upstream of or within positive regulation of hippo signaling IDA
IDA: 通过直接分析推断
22292086 GOA
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
19962960 GOA
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
19962960 GOA
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
11805089 GOA
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
16751106 GOA
involved in protein import into nucleus IGI
IGI: 通过遗传相互作用推断
16751106 GOA
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
11805089 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
8566796 GOA
acts upstream of or within protein stabilization IDA
IDA: 通过直接分析推断
19962960 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
35429439 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17932490 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17932490 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
19962960 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STK4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (31 - 281)

Mst1_SARAH

Mst1_SARAH: C terminal SARAH domain of Mst1 (432 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase 4

STE20-like kinase MST1

STK4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
BioID
24255178
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
24366813
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
20920251
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
16930133
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
20562859
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
TAP
24981860
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
24255178
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
TAP
23455922
种属内
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
TAP
23386615
种属内
STK4 Q13043 SLMAP Homo sapiens Q14BN4
BioID
24255178
种属内
STK4 Q13043 SLMAP Homo sapiens Q14BN4
Anti Tag CoIP
35271311
种属内
STK4 Q13043 SLMAP Homo sapiens Q14BN4
Anti Tag CoIP
24366813
种属间
STK4 Q13043 Stk38 Mus musculus Q91VJ4
Protein Kinase Assay
21730291
种属内
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
Anti Tag CoIP
35271311
种属内
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
Anti Tag CoIP
20920251
种属内
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
TAP
23455922
种属内
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
BioID
24255178
种属内
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
Anti Tag CoIP
24366813
种属内
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Anti Tag CoIP
20562859
种属内
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
TAP
23455922
种属内
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Y2H
20920251
种属内
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Anti Tag CoIP
35271311
种属内
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Anti Tag CoIP
24366813
种属内
STK4 Q13043 RASSF6 Homo sapiens Q6ZTQ3
Anti Tag CoIP
24366813
种属内
STK4 Q13043 RASSF6 Homo sapiens Q6ZTQ3
Anti Tag CoIP
35271311
种属内
STK4 Q13043 RASSF6 Homo sapiens Q6ZTQ3
Anti Tag CoIP
20920251
种属内
STK4 Q13043 AKT1 Homo sapiens P31749
Anti Bait CoIP
17932490
种属内
STK4 Q13043 AKT1 Homo sapiens P31749
Anti Tag CoIP
17932490
种属内
STK4 Q13043 AKT1 Homo sapiens P31749
IF
17932490
种属内
STK4 Q13043 PRDX1 Homo sapiens Q06830
TAP
23386615
种属内
STK4 Q13043 PRDX1 Homo sapiens Q06830
Anti Tag CoIP
23386615
种属内
STK4 Q13043 PRDX1 Homo sapiens Q06830
Protein Kinase Assay
23386615
种属内
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
TAP
24981860
种属内
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
Anti Tag CoIP
20562859
种属内
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
TAP
23455922
种属内
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
BioID
24255178
种属内
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
Anti Tag CoIP
24366813
种属内
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
Anti Tag CoIP
35271311
种属内
STK4 Q13043 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
种属内
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
CoIP
15109305
种属内
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
Y2H
14729613
种属内
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
Anti Tag CoIP
20920251
种属内
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
Y2H
20920251
种属间
STK4 Q13043 Prdx1 Mus musculus P35700
Anti Tag CoIP
21516123
种属间
STK4 Q13043 Prdx1 Mus musculus P35700
Protein Kinase Assay
21516123
种属内
STK4 Q13043 GABARAP Homo sapiens O95166
Pull Down
20562859
种属内
STK4 Q13043 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
种属内
STK4 Q13043 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
种属内
STK4 Q13043 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
24255178
种属内
STK4 Q13043 MOB1A Homo sapiens Q9H8S9
Protein Kinase Assay
21516123
种属内
STK4 Q13043 MOB1A Homo sapiens Q9H8S9
TAP
23386615
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
35271311
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
20920251
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
TAP
23386615
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
TAP
24981860
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
Y2H
20920251
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
20562859
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
24255178
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
TAP
23455922
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
BioID
24255178
种属内
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
24366813
种属内
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0-3
Y2H
20920251
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
24255178
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
TAP
23455922
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
BioID
24255178
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
TAP
23386615
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
35271311
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
24366813
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
TAP
24981860
种属内
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
20562859
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 STK4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74742 MST1/STK4 Protein, Human (sf9, His) Q13043 (E2-F487) ≥95%

关联疾病

疾病名称 别名
T-Cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations

Combined Immunodeficiency Due To Stk4 Deficiency

TIIAC

Stk4 Deficiency

Mst1 Deficiency

T-Cell Immunodeficiency, Recurrent Infections, Autoimmunity, And Cardiac Malformations

Cid Due To Stk4 Deficiency
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity

IMD63

Il2rb Deficiency

Cd122 Deficiency

Immunodeficiency 63

Interleukin 2 Receptor, Beta, Deficiency Of

Deficiency Of Interleukin 2 Receptor Beta
Lymphoproliferative Syndrome 2

Cd27 Deficiency

LPFS2

Combined Immunodeficiency Due To Cd27 Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Coronin-1a Deficiency
Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132969 SBP-3264 98.63% 否
HY-RS13941 STK4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus STK4 VGNC VGNC:81228
Rattus norvegicus STK4 RGD RGD:1312035
Mus musculus STK4 MGD MGI:1929004
Canis familiaris STK4 VGNC VGNC:46922
Bos taurus STK4 VGNC VGNC:35401
Macaca mulatta STK4 VGNC VGNC:81588
Others STK4 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z