Tlr8 - toll-like receptor 8 Gene

中文名称：Toll 样受体 8

种属: Rattus norvegicus

基因 ID: 684440 | 基因类型: protein coding

关于 Tlr8

Primary_assembly X: 27,091,778-27,116,549 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 199 orthologues, 26 paralogues and is associated with 10 phenotypes. Biased expression in Spleen (RPKM 165.1), Lung (RPKM 67.6) and 7 other tissues.

功能概要

预测该基因编码的蛋白具有相同的蛋白质结合活性；核酸结合活性；和模式识别受体活性。预计参与多个过程，包括细胞对机械刺激的反应；白细胞介素 12 产生的负调节；和细胞因子产生的正调节。预测作用于蛋白质磷酸化调节的上游或调节之内。预计位于质膜外侧。预计在质膜上有活性。与人类 TLR8（toll 样受体 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; negative regulation of interleukin-12 production; and positive regulation of cytokine production. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Tlr8 基因产物(1)

mRNA	Protein	Name
NM_001101009.1	NP_001094479.1	toll-like receptor 8 precursor

Tlr8 蛋白结构

PRK15370

LRR_RI

PLN00113

LRR_RI

PRK15370

LRR_RI

PCC

TIR

0
200
400
600
800
1029 a.a.

蛋白主名

其他名称

toll-like receptor 8

相关产品

Clinical Phase

生物活性分子 (7)

目录号	产品名	作用方式	纯度	Phase
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-134581	Enpatoran	Inhibitor	99.80%	Phase 2
HY-13773	Motolimod	Agonist	98.12%	Phase 2
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.33%	Phase 2
HY-109137	Selgantolimod	Agonist	98.23%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.98%	Phase 1

Pre-clinical Phase

生物活性分子 (38)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-128799	CL097	Agonist	99.89%	否
HY-117066	CL075	Agonist	99.25%	否
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	否
HY-103698A	TLR7/8 agonist 1 dihydrochloride	Agonist	99.70%	否
HY-103697	Gardiquimod	Agonist	99.91%	否
HY-103698	TLR7/8 agonist 1	Agonist	97.33%	否
HY-103697A	Gardiquimod diTFA	Agonist	≥99.0%	否
HY-112050	CU-CPT-8m	Antagonist	99.98%	否
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	否
HY-112667	CU-CPT-9a	Antagonist	99.36%	否
HY-101929	CU-CPT17e	Agonist	99.00%	否
HY-160229	ssRNA40 sodium	Activator	93.25%	否
HY-131945	CU-115	Antagonist	99.55%	否
HY-112051	CU-CPT9b	Antagonist	99.03%	否
HY-139017	TLR7/8 agonist 4	Agonist	99.04%	否
HY-10018	Toll-like receptor modulator	Modulator	99.36%	否
HY-128799A	CL097 hydrochloride	Agonist	99.90%	否
HY-13740S	Resiquimod-d5	Agonist	99.84%	否
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	否
HY-153543	TLR7/8 agonist 8	Agonist	98.69%	否
HY-158694A	TLR7 agonist 20 hydrochloride	Agonist	99.86%	否
HY-159102	PVP-037.2	Agonist	/	否
HY-138139A	AXC-715 hydrochloride	Agonist	99.46%	否
HY-141454	TLR8 agonist 2	Agonist	/	否
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	否
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	否
HY-158694	TLR7 agonist 20	Agonist	/	否
HY-121496	3M-011	Agonist	/	否
HY-160228	ORN 02	Activator	/	否
HY-162845	TLR7/8 agonist 11	Agonist	/	否
HY-161630	TLR8 agonist 8	Agonist	/	否
HY-161629	TLR8 agonist 7	Agonist	/	否
HY-163670	TLR7 agonist 21	Inhibitor	/	否
HY-169057	BI1543673	Inhibitor	/	否
HY-161631	TLR8 agonist 9	Agonist	/	否
HY-160228A	ORN 02 sodium	Activator	/	否
HY-159919	UM-3006	Agonist	/	否
HY-159916	AYK004	Agonist	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Tlr8	NCBI	NCBI:51311

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