2. Gene
  3. TEAD1 - TEA domain transcription factor 1 Gene

TEAD1 - TEA domain transcription factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TEA 域转录因子 1

种属: Homo sapiens

同用名: AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1

基因 ID: 7003 | 基因类型: protein coding

关于 TEAD1

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:12,674,421-12,944,737 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 17.6), esophagus (RPKM 16.7) and 24 other tissues.

功能概要

该基因编码一种普遍存在的转录增强因子，它是 TEA/ATTS 结构域家族的成员。这种蛋白质指导多种基因的反式激活，并且在胎盘细胞中还充当转录抑制因子。该基因的突变导致 Sveinsson 的脉络膜视网膜萎缩。已经描述了其他转录本变体，但它们的全长性质尚未经过实验验证。[RefSeq 提供，2010 年 5 月]

This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

TEAD1 基因产物(1)

mRNA Protein Name
NM_021961.6 NP_068780.2 transcriptional enhancer factor TEF-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
18579750 GOA
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
20123905 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
26045994 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
26045994 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9869635 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in hippo signaling IDA
IDA: 通过直接分析推断
18579750 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20123905 GOA
involved in positive regulation of cell growth IDA
IDA: 通过直接分析推断
18579750 GOA
involved in positive regulation of miRNA transcription IMP
IMP: 通过突变表型推断
26045994 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20123905 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25796446 GOA
involved in protein-containing complex assembly IMP
IMP: 通过突变表型推断
20123905 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of TEAD-YAP complex IDA
IDA: 通过直接分析推断
20123905 GOA
part of TEAD-YAP complex IPI
IPI: 通过物理相互作用推断
25384421 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TEAD1 蛋白结构

TEA

TEA: TEA/ATTS domain family (9 - 418)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
蛋白主名 其他名称

transcriptional enhancer factor TEF-1

TEA domain family member 1 (SV40 transcriptional enhancer factor)

TEAD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TEAD1 P28347 YAP1 Homo sapiens P46937
Anti Tag CoIP
26258633
种属内
TEAD1 P28347 YAP1 Homo sapiens P46937
BioID
35140242
种属内
TEAD1 P28347 YAP1 Homo sapiens P46937
Anti Bait CoIP
26258633
种属内
TEAD1 P28347 YAP1 Homo sapiens P46937
Anti Bait CoIP
24882516
种属内
TEAD1 P28347 RAD51 Homo sapiens Q06609
Anti Tag CoIP
33961781
种属内
TEAD1 P28347 RAD51 Homo sapiens Q06609
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

TEAD1 抗体

目录号 产品名 应用 反应物种
HY-P82209 Transcriptional Enhancer Factor TEF 1 Antibody (YA1954) WB, IHC-P, IP Human, Mouse, Rat
HY-P82377 Transcriptional Enhancer Factor TEF Antibody (YA2122) WB Human

关联疾病

疾病名称 别名
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Aicardi Syndrome

AIC

Corpus Callosum, Agenesis Of, With Chorioretinal Abnormality

Agenesis Of Corpus Callosum With Chorioretinal Abnormality

Aicardi'S Syndrome

Agenesis Of Corpus Callosum With Infantile Spasms And Ocular Abnormalities

Callosal Agenesis And Ocular Abnormalities

Chorioretinal Anomalies With Acc
Spindle Cell Rhabdomyosarcoma
Neurofibroma

Neurofibromas

Neurofibromatoses

Nerve Sheath Tumors
Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal

Rhabdomyosarcoma Embryonal

Botryoid Rhabdomyosarcoma

Erms

Spindle Cell Rhabdomyosarcomas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134956 VT104 Inhibitor 99.94% 否
HY-134955 VT103 Inhibitor 99.26% 否
HY-P2244A YAP-TEAD-IN-1 TFA Inhibitor 99.75% 否
HY-147208 MSC-4106 Inhibitor 99.82% 否
HY-147088 TEAD-IN-2 Inhibitor 98.93% 否
HY-P2244 YAP-TEAD-IN-1 Inhibitor 99.69% 否
HY-161443 TEAD-IN-9 Inhibitor / 否
HY-161568 TEAD-IN-10 Inhibitor / 否
HY-161569 TEAD-IN-11 Inhibitor / 否
HY-168506 MSC-1254 Inhibitor / 否
HY-169316 YAP/TAZ inhibitor-4 Inhibitor / 否
HY-RS14342 TEAD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-168505 MSC-5046 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TEAD1 VGNC VGNC:47228
Mus musculus TEAD1 MGD MGI:101876
Macaca mulatta TEAD1 VGNC VGNC:78301
Felis catus TEAD1 VGNC VGNC:66053
Bos taurus TEAD1 VGNC VGNC:35724
Rattus norvegicus TEAD1 RGD RGD:1549742
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z