UGDH - UDP-glucose 6-dehydrogenase Gene

中文名称：UDP-葡萄糖 6-脱氢酶

种属: Homo sapiens

同用名: GDH; UGD; DEE84; EIEE84; UDPGDH; UDP-GlcDH

基因 ID: 7358 | 基因类型: protein coding

关于 UGDH

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,498,755-39,527,439 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and is associated with 1 phenotype. Broad expression in colon (RPKM 31.0), liver (RPKM 26.9) and 23 other tissues.

功能概要

该基因编码的蛋白质将 UDP-葡萄糖转化为 UDP-葡萄糖醛酸，从而参与透明质酸、硫酸软骨素和硫酸乙酰肝素等糖胺聚糖的生物合成。这些糖基化化合物是细胞外基质的常见成分，可能在信号转导、细胞迁移以及癌症生长和转移中发挥作用。该基因的表达受转化生长因子β的上调，受缺氧的影响下调。可变剪接导致多个转录变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and Cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UGDH 基因产物(3)

mRNA	Protein	Name
NM_001184700.2	NP_001171629.1	UDP-glucose 6-dehydrogenase isoform 2
NM_001184701.2	NP_001171630.1	UDP-glucose 6-dehydrogenase isoform 3
NM_003359.4	NP_003350.1	UDP-glucose 6-dehydrogenase isoform 1

UGDH 蛋白结构

UDPG_MGDP_dh_N

UDPG_MGDP_dh

UDPG_MGDP_dh_C

0
100
200
300
400
494 a.a.

蛋白主名

其他名称

UDP-glucose 6-dehydrogenase

UDP-Glc dehydrogenase

UGDH 蛋白互作信息

分类种属内	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UGDH	O60701	TNPO1	Homo sapiens	Q92973	Anti Tag CoIP	35271311
种属内	UGDH	O60701	AK5	Homo sapiens	Q9Y6K8	Y2H Pooling	16169070
种属内	UGDH	O60701	UGDH	Homo sapiens	O60701	Y2H Array	25416956
种属内	UGDH	O60701	RAD51	Homo sapiens	Q06609	Y2H Array	21988832
种属内	UGDH	O60701	UGDH	Homo sapiens	O60701	GMS	32001716
种属内	UGDH	O60701	q5nge3_fratt	Francisella tularensis subsp. tularensis	Q5NGE3	Y2H Pooling	26714771
种属内	UGDH	O60701	ITGB1BP2	Homo sapiens	Q9UKP3	Y2H Fragment Pooling	23414517

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Developmental And Epileptic Encephalopathy 84

DEE84	Jamuar Syndrome
Eiee84	Developmental And Epileptic Encephalopathy, 84
Epileptic Encephalopathy, Early Ifantile, 84	Early Infantile Epileptic Encephalopathy 84
Epileptic Encephalopathy, Early Infantile, 84	Encephalopathy, Epileptic, Early Infantile, Type 84

Galactosemia I

Galactosemia	Galt Deficiency
Classic Galactosemia	Galactose-1-Phosphate Uridylyltransferase Deficiency
Galactose-1-Phosphate Uridyltransferase Deficiency	GALAC1
Galactosemia, Classic	Galactosemia Type 1
Galactosemias	Classical Galactosemia
Galactosaemia	Galactose Intolerance
Epimerase Deficiency Galactosemia	Galactokinase Deficiency Disease
Galactose Epimerase Deficiency	Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease
Gale Deficiency	Galk Deficiency
Udp-Galactose-4-Epimerase Deficiency Disease	Utp Hexose-1-Phosphate Uridylyltransferase Deficiency
Galactosemia 1	Galactosemia, Duarte Variant
Deficiency Of Galactokinase	Udpglucose 4-Epimerase Deficiency Disease
Classical Galactosaemia	Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency
Classic Galactosaemia	Deficiency Of Hexose-1-Phosphate Uridylyltransferase
Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase	Deficiency Of Galactose-1-Phosphate Uridylyltransferase
Galactose-1-Phosphate Uridyl Transferase Deficiency	Transferase Deficiency Galactosemia
Deficiency Of Uridyl Transferase	Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase
Utp-Hexose-1-Phosphate Uridyltransferase Deficiency

Spastic Paraplegia 76, Autosomal Recessive

SPG76	Autosomal Recessive Spastic Paraplegia Type 76
Hereditary Spastic Paraplegia 76	Autosomal Recessive Spastic Paraplegia 76
Paraplegia, Spastic, Autosomal Recessive, Type 76

Galactosemia Iii

Galactose Epimerase Deficiency	Gale Deficiency
Udp-Galactose-4-Epimerase Deficiency	Epimerase Deficiency Galactosemia
Galactosemia Type 3	Gale-D
Uridine Diphosphate Galactose-4-Epimerase Deficiency	GALAC3
Galactosemia 3	Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency
Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency	Galactosemia Type Iii
Udp-Galactose-4'-Epimerase Deficiency	Generalized Galactose Epimerase Deficiency
Generalized Gale Deficiency	Generalized Gale-D
Generalized Udp-Galactose-4-Epimerase Deficiency	Generalized Epimerase Deficiency Galactosemia
Erythrocyte Galactose Epimerase Deficiency	Erythrocyte Gale Deficiency
Erythrocyte Gale-D	Erythrocyte Udp-Galactose-4-Epimerase Deficiency
Erythrocyte Epimerase Deficiency Galactosemia	Galactosemias
Classical Galactosemia	Udpglucose 4-Epimerase Deficiency Disease

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式 Inhibitor Pre-designed Sets	纯度	是否罕见病否
HY-E70020	UDP-Glc dehydrogenase (UGDH)		/	否
HY-170876	UX4O	Inhibitor	/	否
HY-RS15422	UGDH Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	UGDH	MGD	MGI:1306785
Rattus norvegicus	UGDH	RGD	RGD:621879
Macaca mulatta	UGDH	VGNC	VGNC:78711
Felis catus	UGDH	VGNC	VGNC:66805
Bos taurus	UGDH	VGNC	VGNC:36648
Canis familiaris	UGDH	VGNC	VGNC:48117

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UGDH - UDP-glucose 6-dehydrogenase Gene

关于 UGDH

功能概要

UGDH 基因产物(3)

UGDH 蛋白结构

UGDH 蛋白互作信息

关联疾病

直系同源

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UGDH - UDP-glucose 6-dehydrogenase Gene

关于 UGDH

功能概要

UGDH 基因产物(3)

UGDH 蛋白结构

UGDH 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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