Rps6kb1 - ribosomal protein S6 kinase B1 Gene

中文名称：核糖体蛋白 S6 激酶 B1

种属: Rattus norvegicus

同用名: p70 S6K-alpha

基因 ID: 83840 | 基因类型: protein coding

关于 Rps6kb1

Primary_assembly 10: 71,323,777-71,367,908 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 155 orthologues, 7 paralogues and is associated with 17 phenotypes. Biased expression in Muscle (RPKM 16.2), Thymus (RPKM 146.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动； PDZ 域绑定活动；和蛋白磷酸酶 2A 结合活性。涉及多个过程，包括长期记忆；骨骼肌组织生长的正调节；和对肽激素的反应。位于多个细胞成分中，包括细胞表面；胞质溶胶；和细胞质的核周区。在突触中活跃。多种疾病的生物标志物，包括常染色体显性多囊肾病；高胰岛素血症;肌肉萎缩;肥胖;和原发性胆汁性胆管炎。与人 RPS6KB1（核糖体蛋白 S6 激酶 B1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; PDZ domain binding activity; and protein Phosphatase 2A binding activity. Involved in several processes, including long-term memory; positive regulation of skeletal muscle tissue growth; and response to peptide hormone. Located in several cellular components, including cell surface; cytosol; and perinuclear region of cytoplasm. Is active in synapse. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hyperinsulinism; muscular atrophy; obesity; and primary biliary cholangitis. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6kb1 基因产物(1)

mRNA	Protein	Name
NM_031985.1	NP_114191.1	ribosomal protein S6 kinase beta-1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	11574531	RGD
enables PDZ domain binding	IPI IPI: 通过物理相互作用推断	9653190	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17446865	RGD
enables peptide binding	IDA IDA: 通过直接分析推断	11574531	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	9653190	RGD
enables protein kinase activity	IDA IDA: 通过直接分析推断	11574531	RGD
enables protein phosphatase 2A binding	IPI IPI: 通过物理相互作用推断	16899564	RGD
enables ribosomal protein S6 kinase activity	IMP IMP: 通过突变表型推断	11574531	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell migration	IEP IEP: 通过表达模式推断	16710051	RGD
involved in cellular response to hormone stimulus	IEP IEP: 通过表达模式推断	16717100	RGD
involved in long-term memory	IEP IEP: 通过表达模式推断	16885218	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: 通过突变表型推断	18952604	RGD
involved in positive regulation of skeletal muscle tissue growth	IMP IMP: 通过突变表型推断	16408196	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: 通过突变表型推断	16148030	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: 通过突变表型推断	16148030	RGD
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	11574531	RGD
involved in protein phosphorylation	IMP IMP: 通过突变表型推断	9653190	RGD
involved in regulation of D-glucose import	IMP IMP: 通过突变表型推断	18952604	RGD
involved in response to L-leucine	IEP IEP: 通过表达模式推断	16616211	RGD
involved in response to amino acid	IEP IEP: 通过表达模式推断	10913029	RGD
involved in response to electrical stimulus involved in regulation of muscle adaptation	IEP IEP: 通过表达模式推断	15716393	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	15547464	RGD
involved in response to glucagon	IEP IEP: 通过表达模式推断	15494402	RGD
involved in response to glucocorticoid	IEP IEP: 通过表达模式推断	14630710	RGD
involved in response to glucose	IEP IEP: 通过表达模式推断	16885218	RGD
involved in response to insulin	IEP IEP: 通过表达模式推断	15908181	RGD
involved in response to insulin	IMP IMP: 通过突变表型推断	18952604	RGD
involved in response to lipopolysaccharide	IEP IEP: 通过表达模式推断	15389631	RGD
involved in response to mechanical stimulus	IEP IEP: 通过表达模式推断	17526558	RGD
involved in response to nutrient	IEP IEP: 通过表达模式推断	10913029	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	16616211	RGD
involved in response to peptide hormone	IEP IEP: 通过表达模式推断	12668683	RGD
involved in response to testosterone	IEP IEP: 通过表达模式推断	15698549	RGD
involved in response to toxic substance	IEP IEP: 通过表达模式推断	15342961	RGD
involved in response to tumor necrosis factor	IMP IMP: 通过突变表型推断	18952604	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	17728140	RGD
involved in skeletal muscle atrophy	IEP IEP: 通过表达模式推断	17885021	RGD
involved in skeletal muscle contraction	IEP IEP: 通过表达模式推断	15033970	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	16710051	RGD
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	16710051	RGD
is active in postsynapse	IDA IDA: 通过直接分析推断	14623952	RGD
is active in synapse	IDA IDA: 通过直接分析推断	12711090	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rps6kb1 蛋白结构

STKc_p70S6K

0
100
200
300
400
525 a.a.

蛋白主名

其他名称

ribosomal protein S6 kinase beta-1

70 kDa ribosomal protein S6 kinase 1	P70S6K
P70S6K1	S6 kinase
S6K	S6K-beta-1
S6K1	p70 S6 kinase alpha
p70 S6KA	p70 ribosomal S6 kinase alpha
p70(S6K)-alpha	p70-S6K 1
ribosomal protein S6 kinase I	ribosomal protein S6 kinase, 70kDa, polypeptide 1
ribosomal protein S6 kinase, polypeptide 1

Rps6kb1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Rps6kb1	P67999	RPTOR	Homo sapiens	Q8N122	Pull Down	12150926
种属内	Rps6kb1	P67999	Ppp1r9a	Rattus norvegicus	O35867	Pull Down	9653190
种属内	Rps6kb1	P67999	Pdk1	Rattus norvegicus	Q63065	Protein Kinase Assay	17446865
种属内	Rps6kb1	P67999	Rps6kb1	Rattus norvegicus	P67999	Protein Kinase Assay	17446865
种属内	Rps6kb1	P67999	Rps6	Mus musculus	P62754	Protein Kinase Assay	21986499
种属内	Rps6kb1	P67999	Mtor	Mus musculus	Q9JLN9	Protein Kinase Assay	12150926
种属内	Rps6kb1	P67999	Ppp1r9a	Rattus norvegicus	O35867	Anti Tag CoIP	9653190
种属内	Rps6kb1	P67999	Coasy	Rattus norvegicus	Q5XIA5	GMS	15589845
种属内	Rps6kb1	P67999	Rps6kb1	Rattus norvegicus	P67999	Protein Kinase Assay	21986499

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148062	RSS0680		98.03%	否
HY-RS12262	RPS6KB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12263	Rps6kb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12264	Rps6kb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Rps6kb1	NCBI	NCBI:6198

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4