1. Gene
  2. Mtor - mechanistic target of rapamycin kinase Gene

Mtor - mechanistic target of rapamycin kinase Gene

中文名称:雷帕霉素激酶的机制靶点

种属: Mus musculus

同用名: FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; 2610315D21Rik

基因 ID: 56717 | 基因类型: protein coding

关于 Mtor

Chromosome 4: 148,533,068-148,642,140 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 64 phenotypes. Ubiquitous expression in testis adult (RPKM 23.), kidney adult (RPKM 12.8) and 28 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性和核糖体结合活性。参与多个过程,包括“从头”嘧啶核碱基生物合成过程; T-helper 1 细胞谱系承诺;和神经元动作电位。作用于多个过程的上游或内部,包括心脏发育;细胞成分生物合成的正向调节;和蛋白质磷酸化的调节。位于胞质溶胶中;树突;和核。 TORC1 复合体的一部分。与 PML 体共定位。在中枢神经系统中表达;早孕;卵母细胞;呼吸系统;和视网膜。该基因的人类直系同源物与常染色体显性多囊肾病有关;肾血管平滑肌脂肪瘤;肺部疾病(多发);前列腺癌;和 2 型糖尿病。与人 mTOR 同源(雷帕霉素激酶的机制靶标)。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human mTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mtor 基因产物(1)

mRNA Protein Name
NM_020009.2 NP_064393.2 serine/threonine-protein kinase mTOR
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12150926 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11707573 MGI
enables ribosome binding IDA
IDA: 通过直接分析推断
21045808 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 'de novo' pyrimidine nucleobase biosynthetic process IDA
IDA: 通过直接分析推断
23429704 MGI
involved in T-helper 1 cell lineage commitment IMP
IMP: 通过突变表型推断
26410627 MGI
involved in TOR signaling IGI
IGI: 通过遗传相互作用推断
26160071 MGI
involved in TOR signaling IMP
IMP: 通过突变表型推断
15485918 MGI
involved in behavioral response to pain IGI
IGI: 通过遗传相互作用推断
31874168 MGI
acts upstream of calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
18347059 MGI
involved in cardiac cell development IMP
IMP: 通过突变表型推断
23342106 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within cardiac muscle contraction IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within cell projection organization IMP
IMP: 通过突变表型推断
16286931 MGI
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
16915281 MGI
involved in cellular response to nutrient levels IDA
IDA: 通过直接分析推断
21258367 MGI
acts upstream of or within energy reserve metabolic process IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within germ cell development IDA
IDA: 通过直接分析推断
12140361 MGI
acts upstream of or within heart morphogenesis IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within heart valve morphogenesis IMP
IMP: 通过突变表型推断
25139234 MGI
involved in inflammatory response IGI
IGI: 通过遗传相互作用推断
31874168 MGI
acts upstream of macroautophagy IMP
IMP: 通过突变表型推断
16714284 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
25139234 MGI
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
21258367 MGI
acts upstream of or within negative regulation of calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
18347059 MGI
acts upstream of or within negative regulation of cell size IGI
IGI: 通过遗传相互作用推断
15185396 MGI
acts upstream of or within negative regulation of macroautophagy IMP
IMP: 通过突变表型推断
16714284 MGI
involved in neuronal action potential IGI
IGI: 通过遗传相互作用推断
31874168 MGI
acts upstream of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
25411504 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
24011591 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
18347059 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
11707573 MGI
acts upstream of or within positive regulation of actin filament polymerization IDA
IDA: 通过直接分析推断
15467718 MGI
acts upstream of or within positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
15467718 MGI
acts upstream of or within positive regulation of lamellipodium assembly IDA
IDA: 通过直接分析推断
15467718 MGI
acts upstream of or within positive regulation of myotube differentiation IGI
IGI: 通过遗传相互作用推断
19704009 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
25411504 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
15467718 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within positive regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
15467718 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within regulation of GTPase activity IMP
IMP: 通过突变表型推断
15467718 MGI
involved in regulation of autophagy IDA
IDA: 通过直接分析推断
24011591 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
29750810 MGI
involved in regulation of locomotor rhythm IMP
IMP: 通过突变表型推断
29750810 MGI
acts upstream of or within regulation of membrane permeability IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within regulation of myelination IMP
IMP: 通过突变表型推断
24101522 MGI
involved in regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
19440205 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
25139234 MGI
acts upstream of or within regulation of protein kinase activity IGI
IGI: 通过遗传相互作用推断
15185396 MGI
acts upstream of or within regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
17556672 MGI
acts upstream of or within response to amino acid IDA
IDA: 通过直接分析推断
15467718 MGI
involved in response to heat IGI
IGI: 通过遗传相互作用推断
31874168 MGI
acts upstream of or within response to insulin IDA
IDA: 通过直接分析推断
15467718 MGI
acts upstream of or within ruffle organization IDA
IDA: 通过直接分析推断
15467718 MGI
acts upstream of or within voluntary musculoskeletal movement IMP
IMP: 通过突变表型推断
25139234 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with PML body IDA
IDA: 通过直接分析推断
16915281 MGI
part of TORC1 complex IDA
IDA: 通过直接分析推断
12718876 MGI
located in cytosol IDA
IDA: 通过直接分析推断
16915281 MGI
located in dendrite IDA
IDA: 通过直接分析推断
23836929 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18347059 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Mtor 蛋白结构

TEL1

TEL1: COG5032 (362 - 2548)

HEAT

HEAT: sd00044 (654 - 680)

HEAT

HEAT: sd00044 (690 - 720)

HEAT

HEAT: sd00044 (728 - 758)

HEAT

HEAT: sd00044 (771 - 804)

HEAT

HEAT: sd00044 (816 - 846)

HEAT

HEAT: sd00044 (954 - 980)

HEAT

HEAT: sd00044 (992 - 1020)

HEAT

HEAT: sd00044 (1032 - 1061)

HEAT

HEAT: sd00044 (1072 - 1098)

HEAT

HEAT: sd00044 (1110 - 1141)

HEAT

HEAT: sd00044 (1153 - 1179)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2549 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase mTOR

FK506 binding protein 12-rapamycin associated protein 1

FK506-binding protein 12-rapamycin complex-associated protein 1

FKBP-rapamycin associated protein (FRAP)

FKBP12-rapamycin complex-associated protein

angiopoietin-like factor CDT6

mammalian target of rapamycin

mechanistic target of rapamycin (serine/threonine kinase)

rapamycin target protein 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mtor NCBI NCBI:2475