Pick1 - protein interacting with PRKCA 1 Gene

种属: Rattus norvegicus

同用名: Prkcabp

基因 ID: 84591 | 基因类型: protein coding

关于 Pick1

功能概要

Enables several functions, including Arp2/3 complex binding activity; SNAP receptor activity; and signaling receptor binding activity. Involved in several processes, including dendritic spine maintenance; long-term synaptic depression; and regulation of receptor internalization. Located in several cellular components, including cytoplasmic vesicle; perinuclear region of cytoplasm; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Apr 2022]

Pick1 基因产物(1)

mRNA	Protein	Name
NM_053460.2	NP_445912.2	PRKCA-binding protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables Arp2/3 complex binding	IDA IDA: 通过直接分析推断	18297063	RGD
enables G protein-coupled glutamate receptor binding	IPI IPI: 通过物理相互作用推断	11007882	RGD
enables G protein-coupled receptor binding	IPI IPI: 通过物理相互作用推断	24749734	RGD
enables SNAP receptor activity	IDA IDA: 通过直接分析推断	11931741	RGD
enables actin filament binding	IDA IDA: 通过直接分析推断	18297063	RGD
enables cytoskeletal protein binding	IPI IPI: 通过物理相互作用推断	18297063	RGD
enables identical protein binding	IDA IDA: 通过直接分析推断	10027300	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	10027300	RGD
enables ionotropic glutamate receptor binding	IPI IPI: 通过物理相互作用推断	11931741	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	10027300	RGD
enables protein domain specific binding	IMP IMP: 通过突变表型推断	18032668	RGD
enables protein kinase C binding	IDA IDA: 通过直接分析推断	15774468	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to decreased oxygen levels	IMP IMP: 通过突变表型推断	23843614	RGD
involved in cellular response to glucose starvation	IMP IMP: 通过突变表型推断	23843614	RGD
involved in dendritic spine maintenance	IMP IMP: 通过突变表型推断	18297063	RGD
involved in dendritic spine organization	IDA IDA: 通过直接分析推断	21252856	RGD
involved in glial cell development	IMP IMP: 通过突变表型推断	23843614	RGD
involved in long-term synaptic depression	IDA IDA: 通过直接分析推断	21252856	RGD
involved in negative regulation of Arp2/3 complex-mediated actin nucleation	IDA IDA: 通过直接分析推断	18297063	RGD
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	24749734	RGD
involved in positive regulation of receptor internalization	IDA IDA: 通过直接分析推断	18297063	RGD
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	11237868	RGD
involved in receptor clustering	IMP IMP: 通过突变表型推断	10027300	RGD
involved in regulation of kainate selective glutamate receptor activity	IMP IMP: 通过突变表型推断	12597860	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: 通过直接分析推断	28855251	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: 通过表达模式推断	28855251	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: 通过突变表型推断	28855251	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in dendrite	IDA IDA: 通过直接分析推断	18032668	RGD
located in dendritic spine	IDA IDA: 通过直接分析推断	11007883	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	19071197	RGD
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	28855251	RGD
located in neuron projection	IDA IDA: 通过直接分析推断	18297063	RGD
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	18032668	RGD
located in postsynaptic density	IDA IDA: 通过直接分析推断	10027300	RGD
is active in postsynaptic endocytic zone	IDA IDA: 通过直接分析推断	28855251	RGD
is active in postsynaptic endocytic zone	IMP IMP: 通过突变表型推断	28855251	RGD
is active in postsynaptic specialization	IDA IDA: 通过直接分析推断	19071197	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	10027300	RGD
located in synapse	IDA IDA: 通过直接分析推断	10027300	RGD
is active in synaptic vesicle	IDA IDA: 通过直接分析推断	19071197	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

PRKCA-binding protein

protein interacting with C kinase 1	protein kinase C-alpha-binding protein
protein that interacts with C kinase 1

Pick1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Cross	Pick1	Q9EP80	GRIA2	Homo sapiens	P42262	FPS	20018661
Cross	Pick1	Q9EP80	GRIA2	Homo sapiens	P42262	FRET	20018661
Intra	Pick1	Q9EP80	mGluR7	Rattus norvegicus	Q63337	Y2H	11891216
Intra	Pick1	Q9EP80	Grm7	Rattus norvegicus	P35400	Anti Bait CoIP	11007882
Intra	Pick1	Q9EP80	Grm7	Rattus norvegicus	P35400	Pull Down	11007882
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Anti Bait CoIP	20018661
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Y2H	10340301
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	IF	17914463
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	CoIP	10340301
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Y2H	10027300
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	IF	10027300
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Anti Bait CoIP	10027300
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Imaging	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Imaging	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	SAXS	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Solution Sedimentation	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Anti Tag CoIP	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Pull Down	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	FRET	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	GMS	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Y2H	10027300
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Crosslink	26073603
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Y2H	10340301
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Y2H	10027300
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Anti Bait CoIP	10027300
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Y2H	11891216
Intra	Pick1	Q9EP80	Btg2	Rattus norvegicus	P27049	Y2H	11237868
Intra	Pick1	Q9EP80	Btg2	Rattus norvegicus	P27049	CoIP	11237868

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117772	FSC231		99.84%	否
HY-RS10479	PICK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Pick1	NCBI	NCBI:9463

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Pick1 - protein interacting with PRKCA 1 Gene

关于 Pick1

功能概要

Pick1 基因产物(1)

Pick1 蛋白互作信息

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

Pick1 - protein interacting with PRKCA 1 Gene

关于 Pick1

功能概要

Pick1 基因产物(1)

Pick1 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z