2. Gene
  3. Grm7 - glutamate metabotropic receptor 7 Gene

Grm7 - glutamate metabotropic receptor 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：谷氨酸代谢受体 7

种属: Rattus norvegicus

基因 ID: 81672 | 基因类型: protein coding

关于 Grm7

Primary_assembly 4: 143,731,259-144,612,344 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 7 phenotypes. Restricted expression toward (RPKM 123.2).

功能概要

该基因编码的蛋白可启动多项功能，包括 PDZ 域绑定活动；钙调蛋白结合活性；和谷氨酸结合活性。参与腺苷酸环化酶抑制G蛋白偶联谷氨酸受体信号通路；谷氨酸分泌的负调节；和神经元凋亡过程的负调控。位于多个细胞成分中，包括树突状轴；粗面内质网;和突触膜。部分含蛋白质复合物。在 GABA 能突触和谷氨酸能突触中活跃。是突触前活动区膜的组成部分。与人类 GRM7（谷氨酸代谢受体 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including PDZ domain binding activity; Calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; rough endoplasmic reticulum; and synaptic membrane. Part of protein-containing complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Grm7 基因产物(1)

mRNA Protein Name
NM_031040.1 NP_112302.1 metabotropic glutamate receptor 7 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
11007882 RGD
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IDA
IDA: 通过直接分析推断
11825890 RGD
enables calcium-dependent protein binding IPI
IPI: 通过物理相互作用推断
21855531 RGD
enables calmodulin binding IPI
IPI: 通过物理相互作用推断
12021391 RGD
enables glutamate binding IDA
IDA: 通过直接分析推断
11825890 RGD
enables group III metabotropic glutamate receptor activity IDA
IDA: 通过直接分析推断
12692128 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17620729 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11891216 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA
IDA: 通过直接分析推断
11825890 RGD
involved in negative regulation of glutamate secretion IDA
IDA: 通过直接分析推断
11825890 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
26621121 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
9295396 RGD
located in asymmetric synapse IDA
IDA: 通过直接分析推断
9300765 RGD
located in axon IDA
IDA: 通过直接分析推断
9300765 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
11825890 RGD
located in cell surface IDA
IDA: 通过直接分析推断
16890965 RGD
located in dendrite IDA
IDA: 通过直接分析推断
9300765 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
12823458 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
8604049 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
8929965 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
8764662 RGD
located in presynaptic active zone IDA
IDA: 通过直接分析推断
8764662 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
9295396 RGD
is active in presynaptic active zone membrane IMP
IMP: 通过突变表型推断
35511883 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
8604049 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
9300765 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
11007882 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
12823458 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Grm7 蛋白结构

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (42 - 510)

NCD3G

NCD3G: pfam07562 (518 - 568)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 613)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 894)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (625 - 646)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (655 - 679)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (701 - 721)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (751 - 777)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (785 - 808)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (818 - 843)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 922 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 7

glutamate receptor, metabotropic 7

mGluR7

metabotropic glutamate receptor mGluR7

metabotropic glutamate receptor subtype 7b

Grm7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Pull Down
11891216
种属内
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Anti Tag CoIP
11007882
种属内
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Y2H Array
11007882
种属内
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Y2H
11891216
种属内
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Pull Down
11007882
种属内
Grm7 P35400 Ppp1cc Rattus norvegicus P63088
Y2H
14519764
种属内
Grm7 P35400 Grip1 Rattus norvegicus P97879
Pull Down
11891216
种属内
Grm7 P35400 Grip1 Rattus norvegicus P97879
Imaging
11891216
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05837 GRM7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05838 Grm7 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05839 Grm7 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grm7 NCBI NCBI:2917
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