FBH1 - F-box DNA helicase 1 Gene

中文名称：F-box DNA 解旋酶 1

种属: Homo sapiens

同用名: Fbx18; hFBH1; FBXO18

关于 FBH1

功能概要

该基因编码 F-box 蛋白家族的一个成员，其成员的特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为三类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。该基因编码的蛋白质属于 Fbx 类。它包含一个 F-box 基序和七个保守的解旋酶基序，并且具有 DNA 依赖性 ATP 酶和 DNA 解旋活性。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]