HAT1 - histone acetyltransferase 1 Gene

中文名称：组蛋白乙酰转移酶 1

种属: Homo sapiens

同用名: KAT1

关于 HAT1

功能概要

该基因编码的蛋白质是一种 B 型组蛋白乙酰转移酶 (HAT) ，它参与新合成的细胞质组蛋白的快速乙酰化，这些组蛋白又被导入细胞核以从头沉积到新生 DNA 链上。组蛋白乙酰化，尤其是组蛋白 H4，在复制依赖性染色质组装中起重要作用。具体而言，该 HAT 可以乙酰化可溶性组蛋白 H4 而不是核小体组蛋白 H4 的赖氨酸 5 和 12，并且在较小程度上乙酰化组蛋白 H2A 的赖氨酸 5。已经确定了该基因的选择性剪接转录变体。[RefSeq 提供，2009 年 6 月]

The protein encoded by this gene is a type B Histone Acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]