H2BC12 - H2B clustered histone 12 Gene

中文名称：H2B 成簇组蛋白 12

种属: Homo sapiens

同用名: H2BK; H2B/S; H2BFT; H2BFAiii; HIST1H2BK

关于 H2BC12

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。四个核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一个的两个分子形成一个八聚体，大约 146 bp 的 DNA 被包裹在称为核小体的重复单元中。接头组蛋白 H1 与核小体之间的接头 DNA 相互作用，并在将染色质压缩成更高级结构中发挥作用。该基因编码复制依赖组蛋白，该组蛋白是组蛋白 H2B 家族的成员。所编码的蛋白质是一种具有抗菌和抗真菌活性的抗菌蛋白。已为该基因鉴定出编码相同蛋白质的两个转录本，该基因位于染色体 6p21.33 上的组蛋白微簇中。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with Antibacterial and Antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]