2. Gene
  3. DGAT1 - diacylglycerol O-acyltransferase 1 Gene

DGAT1 - diacylglycerol O-acyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二酰甘油 O-酰基转移酶 1

种属: Homo sapiens

同用名: ARAT; DGAT; ARGP1; DIAR7

基因 ID: 8694 | 基因类型: protein coding

关于 DGAT1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,314,584-144,326,852 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 262 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in small intestine (RPKM 98.7), duodenum (RPKM 96.5) and 20 other tissues.

功能概要

该基因编码一种多通道跨膜蛋白，作为一种关键的代谢酶发挥作用。编码的蛋白质催化二酰甘油和脂肪酰辅酶 A 转化为三酰甘油。这种酶还可以将酰基 CoA 转移到视黄醇。这种蛋白质的活性可能与肥胖和其他代谢疾病有关。[RefSeq 提供，2013 年 7 月]

This gene encodes an multipass transmembrane protein that functions as a key metabolic Enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This Enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and Other metabolic diseases. [provided by RefSeq, Jul 2013]

DGAT1 基因产物(1)

mRNA Protein Name
NM_012079.6 NP_036211.2 diacylglycerol O-acyltransferase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables diacylglycerol O-acyltransferase activity IDA
IDA: 通过直接分析推断
18458083 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32433610 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23420847 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in diacylglycerol metabolic process IDA
IDA: 通过直接分析推断
32433610 GOA
involved in monoacylglycerol biosynthetic process IDA
IDA: 通过直接分析推断
28420705 GOA
acts upstream of or within triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
18458083 GOA
involved in triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
18238778 GOA
involved in very-low-density lipoprotein particle assembly IMP
IMP: 通过突变表型推断
15308631 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
32433610 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DGAT1 蛋白结构

MBOAT

MBOAT: MBOAT, membrane-bound O-acyltransferase family (162 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
蛋白主名 其他名称

diacylglycerol O-acyltransferase 1

ACAT related gene product 1

DGAT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DGAT1 O75907 DGAT1 Homo sapiens O75907
3D-EM
32433610
种属内
DGAT1 O75907 GABRA4 Homo sapiens P48169
Y2H Array
21988832
种属内
DGAT1 O75907 DGAT1 Homo sapiens O75907
GMS
32433610
种属内
DGAT1 O75907 CCR9 Homo sapiens P51686
Ub Reconstruction
28298427
种属内
DGAT1 O75907 DGAT1 Homo sapiens O75907
3D-EM
32433611
种属间: 跨种属相互作用 种属内: 同种属相互作用

DGAT1 抗体

目录号 产品名 应用 反应物种
HY-P81246 DGAT1 Antibody WB, IHC-P, IHC-F, ICC/IF, ELISA Human

关联疾病

疾病名称 别名
Congenital Diarrhea 7 With Exudative Enteropathy

Congenital Chronic Diarrhea With Exudative Enteropathy

Congenital Chronic Diarrhea With Protein-Losing Enteropathy

Congenital Chronic Diarrhoea With Exudative Enteropathy

Congenital Chronic Diarrhoea With Protein-Losing Enteropathy

Congenital Diarrhoea 7 With Exudative Enteropathy
Diarrhea 7, Protein-Losing Enteropathy Type

DIAR7
Protein-Losing Enteropathy

Protein-Losing Enteropathies

Enteropathy, Exudative

Exudative Enteropathy

Ple - [Protein-Losing Enteropathy]
Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency

Familial Chylomicronemia Syndrome

Lpl Deficiency

Hyperchylomicronemia, Familial

Hyperlipemia, Idiopathic, Burger-Grutz Type

Hyperlipemia, Essential Familial

Lipase D Deficiency

Lipd Deficiency

Hyperlipoproteinemia, Type Ia

Chylomicronemia, Familial

High Density Lipoprotein Cholesterol Level Qtl 11

Hyperlipoproteinemia Type 1

Hyperlipoproteinemia 1

HLPP1

Lipoprotein Lipase

Hyperlipoproteinemia Type I

Familial Hyperchylomicronemia Syndrome
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Congenital Diarrhea
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Lipid Metabolism Disorder

Dyslipidemia

Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors

Dyslipidemias

Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-16278 Pradigastat Inhibitor 98.88% Phase 3
HY-13009 PF-04620110 Inhibitor 98.86% Phase 1
HY-15497 AZD7687 Inhibitor 99.80% Phase 1
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10038 A 922500 Inhibitor 99.33% 否
HY-32219 T863 Inhibitor 99.97% 否
HY-12425 DGAT1-IN-1 Inhibitor ≥98.0% 否
HY-50861 AZD3988 Inhibitor 99.83% 否
HY-50670 DGAT-1 inhibitor 2 Inhibitor 95.70% 否
HY-141572 1,2-Dioleoyl-sn-glycerol 99.96% 否
HY-16434 DGAT1-IN-3 Inhibitor 99.92% 否
HY-15197 ABT-046 Inhibitor 98.13% 否
HY-118386 H2-005 / 否
HY-16278A Pradigastat sodium Inhibitor / 否
HY-N7281 Aphadilactone C Inhibitor / 否
HY-RS03710 DGAT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-136707 DGAT-1 inhibitor 3 Inhibitor / 否
HY-16266 JNJ-DGAT1-A Inhibitor / 否
HY-N9153A Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether / 否
HY-111417 GSK2973980A Inhibitor / 否
HY-112851 Diacylglycerol acyltransferase inhibitor-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DGAT1 VGNC VGNC:61455
Rattus norvegicus DGAT1 RGD RGD:628673
Macaca mulatta DGAT1 VGNC VGNC:71776
Canis familiaris DGAT1 VGNC VGNC:39912
Mus musculus DGAT1 MGD MGI:1333825
Bos taurus DGAT1 VGNC VGNC:28020
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