2. Gene
  3. MSC - musculin Gene

MSC - musculin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌肉蛋白

种属: Homo sapiens

同用名: ABF1; MYOR; ABF-1; bHLHa22

基因 ID: 9242 | 基因类型: protein coding

关于 MSC

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:71,841,560-71,844,412 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 13 paralogues. Broad expression in placenta (RPKM 12.2), gall bladder (RPKM 7.2) and 23 other tissues.

功能概要

由该基因编码的蛋白质是一种转录抑制因子，能够在体外以同二聚体或异二聚体的形式与 E2A 结合 E-box 元件。编码的蛋白质还在体内与 E2A 蛋白质形成异二聚体。该蛋白能够抑制哺乳动物细胞中 E47 (一种 E2A 蛋白) 的反式激活能力。该基因是 B 细胞受体信号转导通路的下游靶标。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

MSC 基因产物(1)

mRNA Protein Name
NM_005098.4 NP_005089.2 musculin
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9584154 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MSC 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (108 - 160)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

musculin

activated B-cell factor 1, homolog of mouse musculin

MSC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MSC O60682 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
种属内
MSC O60682 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
种属内
MSC O60682 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
种属内
MSC O60682 TCF4 Homo sapiens P15884-3
Validated Y2H
32296183
种属内
MSC O60682 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
种属内
MSC O60682 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
种属内
MSC O60682 PBX2 Homo sapiens P40425
Validated Y2H
32296183
种属内
MSC O60682 PBX2 Homo sapiens P40425
Y2H Array
32296183
种属内
MSC O60682 PBX2 Homo sapiens P40425
Y2H Prey Pooling
32296183
种属内
MSC O60682 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
种属内
MSC O60682 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
种属内
MSC O60682 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
种属内
MSC O60682 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3

ARCI3

Lamellar Ichthyosis 5

Collodion Baby, Self-Healing

Ichthyosis, Lamellar, 5, Formerly

Li5, Formerly

Li5

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 3
Rhabdomyosarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12042 Pimasertib Inhibitor 99.88% Phase 2
HY-135827A Roginolisib hemifumarate Inhibitor 99.80% Phase 2
HY-100501 M2698 Inhibitor 99.87% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990461 Anti-LIF Antibody (MSC-1) Inhibitor 98.51% Phase 1
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1410 GsMTx4 Inhibitor 99.80% 否
HY-P1410A GsMTx4 TFA Inhibitor 99.80% 否
HY-123872 MSC1094308 Inhibitor 99.89% 否
HY-P1410C D-GsMTx4 TFA Inhibitor 99.89% 否
HY-101611 MSC2530818 Inhibitor 99.62% 否
HY-147208 MSC-4106 Inhibitor 99.82% 否
HY-132301 MSC-4381 Inhibitor 98.89% 否
HY-P1410B D-GsMTx4 Inhibitor 99.59% 否
HY-148518 MSC-1186 Inhibitor 99.42% 否
HY-101215 Evobrutinib Inhibitor 98.70% 是
HY-N0898A (-)-Catechin Inhibitor 98.78% 否
HY-135827 Roginolisib Inhibitor 99.89% 否
HY-108628 SU16f Inhibitor 99.09% 否
HY-110218 CW 008 Agonist 98.15% 否
HY-N0008 Orcinol glucoside 99.57% 否
HY-123851 MSC2504877 Inhibitor 98.50% 否
HY-B1890 (±)-Catechin Inhibitor 98.38% 否
HY-126225 SJA710-6 99.62% 否
HY-131032 KI-7 Agonist 99.16% 否
HY-108438 TCS 2210 Inducer / 否
HY-110262 MSC 2032964A Inhibitor / 否
HY-113568 CAY10581 Inhibitor / 否
HY-12042A Pimasertib hydrochloride Inhibitor / 否
HY-147511 PPARγ agonist 7 Agonist / 否
HY-160053 Gint4.T aptamer sodium Chemical / 否
HY-168506 MSC-1254 Inhibitor / 否
HY-170581 PPARγ/δ modulator 2 Modulator / 否
HY-N8917 (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane Activator / 否
HY-RS08707 MSC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-153332 Tankyrase-IN-5 Inhibitor / 否
HY-168505 MSC-5046 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MSC VGNC VGNC:43436
Rattus norvegicus MSC RGD RGD:1305496
Bos taurus MSC VGNC VGNC:31691
Macaca mulatta MSC VGNC VGNC:74930
Mus musculus MSC MGD MGI:1333884
Others MSC NCBI
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