2. Membrane Transporter/Ion Channel
  3. GLUT
  4. GLUT1-IN-1

GLUT1-IN-1 是一种葡萄糖转运蛋白 1 (GLUT1) 抑制剂，具有 GLUT1 特异性失活能力。GLUT1-IN-1 对 HeLa、A549 和 HepG2 细胞具有浓度依赖性细胞毒性，IC50 值分别为 5.49 μM，11.14 μM 和 8.73 μM。GLUT1-IN-1 可用于光动力疗法（PDT）和癌症的研究。

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GLUT1-IN-1 Chemical Structure

GLUT1-IN-1 Chemical Structure

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GLUT1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 GLUT 亚型特异性产品:

查看所有亚型
GLUT1 GLUT2 GLUT3 GLUT4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer[1].

IC50 & Target[1]

GLUT1

 

体外研究
(In Vitro)

GLUT1-IN-1(compound 8) (0-100 μM; 1 h) exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49, 11.14, and 8.73 μM, respectively (Under light irradiation) [1].
GLUT1-IN-1 (0-100 μM; 1 h) possesses sufficient photosensitizing ability to exhibit significant cytotoxicity and that the glucose conjugation contributes to the suppression of the cytotoxicity of I2BODIPY[1].
GLUT1-IN-1 (8 μM, 10 μM; 1 h) selectively interacts with GLUT1 and oxidizes it under light irradiation, resulting in the conversion of GLUT1 into a derivative that is undetectable by immunoblotting analysis[1].
GLUT1-IN-1(1 h) has a GLUT1-specific inactivation ability and causes lightinduced cytotoxicity by modulating the EGFR/MAPK signaling pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GLUT1-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa, A549 and HepG2 cells
Concentration: 0-100 μM
Incubation Time: 1 h
Result: Exhibited a concentration-dependent cytotoxicity against these cancer cell lines under light irradiation.

Western Blot Analysis[1]

Cell Line: HeLa, A549 and HepG2 cells
Concentration: 10 μM
Incubation Time: 1 h
Result: Not detected GLUT1in cell lines treated with 10 uM under light irradiation.
Reduced the levels of epidermal growth factor receptor tyrosine kinase (EGFR), phospho-ERK (Y204), and GLUT1 without affecting ERK, atubulin, and PCNA protein levels.

Immunofluorescence[1]

Cell Line: HeLa, A549 and HepG2 cells
Concentration: 8, 10 μM
Incubation Time: 1 h
Result: Observed a reduction in the intensity of the fluorescent signals due to glucose transporter 1 (GLUT1).
分子量

830.17

Formula

C25H31BF2I2N6O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GLUT1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLUT1-IN-1GLUTGlucose transporterChromophore-assisted light inactivation (CALI)photodynamic therapy (PDT)glucose transporter 1 (GLUT1)cancer cellsphotosensitizersanhydrase II (CAII)Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151486
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