2. Anti-infection Cell Cycle/DNA Damage Epigenetics
  3. Bacterial DNA/RNA Synthesis MicroRNA Antibiotic
  4. Enoxacin hydrate

Enoxacin hydrate  (Synonyms: 依诺沙星倍半水合物; Enoxacin sesquihydrate; AT-2266 hydrate; CI-919 hydrate)

目录号: HY-B0268A 纯度: 99.85%
COA 产品使用指南

摩尔计算器

Enoxacin hydrate (Enoxacin sesquihydrate) 是一种氟喹诺酮，可以干扰 DNA 复制，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。Enoxacin hydrate 是一种 miRNA 加工激活剂，可增强 siRNA 介导的 mRNA 降解并促进内源性 miRNA 的生物发生，也可增强 TAR RNA 结合蛋白 2 (TRBP) 介导的 microRNA 加工。Enoxacin hydrate 有效抑制革兰氏阳性和阴性细菌， 是一种特异性的癌症生长抑制剂。

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Enoxacin hydrate Chemical Structure

Enoxacin hydrate Chemical Structure

CAS No. : 84294-96-2

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Customer Review

Other Forms of Enoxacin hydrate:

Enoxacin hydrate 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enoxacin hydrate (Enoxacin sesquihydrate), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin hydrate is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin hydrate has potent activities against gram-positive and -negative bacteria. Enoxacin hydrate is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing[1][2][3][4].

IC50 & Target

Quinolone

 

体外研究
(In Vitro)

Enoxacin hydrate (Enoxacin sesquihydrate) increases siGFP-mediated gene knockdown mediated by siRNA against EGFP in HEK293 cells-based reporter system in a dose-dependent manner, with a median effective concentration (EC50) of ~30 µM, whereas it has no effect on the cells expressing GFP only. Enoxacin (50 µM) promotes the processing of miRNAs and the loading of siRNA duplexes onto RISCs in HEK293 cells[3].
Enoxacin has no effect on the processing of pre-let-7 or pre-miR-30a by Dicer alone. However, the addition of Enoxacin can enhance the processing of let-7 or pre-miR-30a by Dicer and TRBP together[3].
Enoxacin inhibits 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enoxacin hydrate 相关抗体:
体内研究
(In Vivo)

Enoxacin hydrate (Enoxacin sesquihydrate; 100 µM; 2 µl; injected into ear once a day for 3 consecutive days (days 12, 13 and 14)) enhances the the GFP mRNA knockdown efficiency by Lv-siGFP (from 80% to 60%; 40% GFP mRNA level remained), whereas alone has no effect on GFP expression in GFP transgenic line C57BL/6-Tg(ACTB-EGFP)1Osb/J (10 d old) with lentivirus expressing shGFP (Lv-siGFP; injected into ear for 10 days)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

347.34

Formula

C15H17FN4O3.3/2H2O
CAS 号
性状

固体

颜色

White to yellow

中文名称

依诺沙星倍半水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

1M NaOH 中的溶解度 : 100 mg/mL (287.90 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO 中的溶解度 : 2.78 mg/mL (8.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8790 mL 14.3951 mL 28.7902 mL
5 mM 0.5758 mL 2.8790 mL 5.7580 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.85%

COA (288 KB) HNMR (250 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

Enoxacin hydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 2.8790 mL 14.3951 mL 28.7902 mL 71.9756 mL
5 mM 0.5758 mL 2.8790 mL 5.7580 mL 14.3951 mL
1M NaOH 10 mM 0.2879 mL 1.4395 mL 2.8790 mL 7.1976 mL
15 mM 0.1919 mL 0.9597 mL 1.9193 mL 4.7984 mL
20 mM 0.1440 mL 0.7198 mL 1.4395 mL 3.5988 mL
25 mM 0.1152 mL 0.5758 mL 1.1516 mL 2.8790 mL
30 mM 0.0960 mL 0.4798 mL 0.9597 mL 2.3992 mL
40 mM 0.0720 mL 0.3599 mL 0.7198 mL 1.7994 mL
50 mM 0.0576 mL 0.2879 mL 0.5758 mL 1.4395 mL
60 mM 0.0480 mL 0.2399 mL 0.4798 mL 1.1996 mL
80 mM 0.0360 mL 0.1799 mL 0.3599 mL 0.8997 mL
100 mM 0.0288 mL 0.1440 mL 0.2879 mL 0.7198 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enoxacin84294-96-2Enoxacin sesquihydrateAT-2266CI-919依诺沙星倍半水合物AT2266AT 2266CI919CI 919BacterialDNA/RNA SynthesisMicroRNAAntibioticmiRNADNAgyrasetopoisomerasesiRNAmRNAgram-positivegram-negativeTAR-RNATRBPInhibitorinhibitorinhibit

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