Hispolon

目录号: HY-150521 纯度: 99.67%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Hispolon 是一种多酚，可从桑黄 (Phellinus linteus) 中分离得到。Hispolon 具有抗癌、抗糖尿病、抗氧化、抗病毒、肝保护活性、抗糖尿病和抗炎活性。

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Hispolon Chemical Structure

CAS No. : 173933-40-9

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规格	价格	是否有货
1 mg	￥600	In-stock
5 mg	￥1550	In-stock
10 mg	￥2500	In-stock
25 mg	￥5000	In-stock
50 mg	￥5900	In-stock
100 mg	现货	询价
200 mg		询价
500 mg		询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A10	IC₅₀	37.05 μg/mL Compound: 1	Antiproliferative activity against rat A10 cells after 24 hrs by MTT assay Antiproliferative activity against rat A10 cells after 24 hrs by MTT assay	[PMID: 22967007]
A549	IC₅₀	0.183 μM Compound: 8	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 15165144]
Bel-7402	IC₅₀	0.038 μM Compound: 8	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay	[PMID: 15165144]
BGC-823	IC₅₀	0.205 μM Compound: 8	Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay	[PMID: 15165144]
DU-145	IC₅₀	28.6 μM Compound: VA-1	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 25842364]
HCT-116	IC₅₀	5.2 μM Compound: VA-1	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 25842364]
HCT-8	IC₅₀	0.199 μM Compound: 8	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 15165144]
HEK293	IC₅₀	7.3 μM Compound: VA-1	Cytotoxicity against HEK293 cells expressing pcDNA3.1 after 72 hrs by MTT assay Cytotoxicity against HEK293 cells expressing pcDNA3.1 after 72 hrs by MTT assay	[PMID: 25842364]
HEK293	IC₅₀	9.6 μM Compound: VA-1	Cytotoxicity against HEK293 cells expressing ABCB1 after 72 hrs by MTT assay Cytotoxicity against HEK293 cells expressing ABCB1 after 72 hrs by MTT assay	[PMID: 25842364]
KETR3	IC₅₀	0.206 μM Compound: 8	Cytotoxicity against human Ketr3 cells after 96 hrs by MTT assay Cytotoxicity against human Ketr3 cells after 96 hrs by MTT assay	[PMID: 15165144]
MCF7	IC₅₀	0.025 μM Compound: 8	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 15165144]
MCF7	IC₅₀	7.9 μM Compound: VA-1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 25842364]
MDA-MB-231	IC₅₀	32.2 μM Compound: VA-1	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 25842364]
MDCK	IC₅₀	36.2 μM Compound: VA-1	Cytotoxicity against MDCK cells after 72 hrs by MTT assay Cytotoxicity against MDCK cells after 72 hrs by MTT assay	[PMID: 25842364]
NIH3T3	IC₅₀	51.2 μM Compound: VA-1	Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by MTT assay	[PMID: 25842364]
PC-3	IC₅₀	12.9 μM Compound: VA-1	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 25842364]
S1	IC₅₀	8.4 μM Compound: VA-1	Cytotoxicity against human S1 cells after 72 hrs by MTT assay Cytotoxicity against human S1 cells after 72 hrs by MTT assay	[PMID: 25842364]

体外研究
(In Vitro)

Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells^[2].
Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells^[2].
Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21^[2].
Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	U87MG cells
Concentration:	25 and 50 μM
Incubation Time:	24, 48, 72 h
Result:	Inhibited cell viability in a dose and time dependent way.

Western Blot Analysis^[2]

Cell Line:	U87MG cells
Concentration:	25 and 50 μM
Incubation Time:	2, 4, 8 h
Result:	Decreased cyclin D4 level, and increased p21 level.

体内研究
(In Vivo)

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice^[3].
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LPS-induced acute lung injury mice^[3]
Dosage:	2.5, 5 and 10 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Alleviated the pathological effects in the LPS-challenged mouse. Reduced the W/D ratio in the lung and MPO activity. Decreased pro-Inflammatory cytokine production.

Animal Model:	DBTRG xenograft mice^[4]
Dosage:	5 and 10 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Reduced tumor volume (RTV). Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.

分子量

220.22

Formula

C₁₂H₁₂O₄

CAS 号

173933-40-9

性状

固体

颜色

Light yellow to yellow

结构分类

初始来源

微生物

Phellinus linteus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 125 mg/mL (567.61 mM; 超声助溶 (<70°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5409 mL	22.7046 mL	45.4091 mL
5 mM	0.9082 mL	4.5409 mL	9.0818 mL
10 mM	0.4541 mL	2.2705 mL	4.5409 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.67%

选择批次：

Data Sheet (603 KB) SDS (251 KB)

COA (167 KB) HNMR (242 KB) LCMS (265 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Sarfraz A, et al. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017.

[2]. Arcella A, et al. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123. [Content Brief]

[3]. Huang CY, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742. [Content Brief]

[4]. Liao KF, et al. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497. [Content Brief]

Hispolon 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5409 mL	22.7046 mL	45.4091 mL	113.5228 mL
	5 mM	0.9082 mL	4.5409 mL	9.0818 mL	22.7046 mL
	10 mM	0.4541 mL	2.2705 mL	4.5409 mL	11.3523 mL
	15 mM	0.3027 mL	1.5136 mL	3.0273 mL	7.5682 mL
	20 mM	0.2270 mL	1.1352 mL	2.2705 mL	5.6761 mL
	25 mM	0.1816 mL	0.9082 mL	1.8164 mL	4.5409 mL
	30 mM	0.1514 mL	0.7568 mL	1.5136 mL	3.7841 mL
	40 mM	0.1135 mL	0.5676 mL	1.1352 mL	2.8381 mL
	50 mM	0.0908 mL	0.4541 mL	0.9082 mL	2.2705 mL
	60 mM	0.0757 mL	0.3784 mL	0.7568 mL	1.8920 mL
	80 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.4190 mL
	100 mM	0.0454 mL	0.2270 mL	0.4541 mL	1.1352 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hispolon173933-40-9AntibioticAnticancerantioxidantanti-inflammatoryU87MGLPSlung injuryInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Hispolon

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