2. Immunology/Inflammation
  3. COX
  4. Ibufenac

Ibufenac  (Synonyms: 4-异丁基苯乙酸; Dytransin)

目录号: HY-W040672 纯度: 98.04%
COA 产品使用指南 技术支持

Ibufenac (Dytransin) 是一种口服活性的非甾体抗炎剂。Ibufenac 发挥抗炎、镇痛和退热作用。Ibufenac 可用于类风湿关节炎等风湿性疾病的治疗研究。

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Ibufenac Chemical Structure

Ibufenac Chemical Structure

CAS No. : 1553-60-2

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥150
In-stock
100 mg ￥137
In-stock
250 mg ￥236
In-stock
500 mg ￥396
In-stock
1 g ￥532
In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

Customer Review

Ibufenac 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis[1][2].

体外研究
(In Vitro)

Ibufenac (60-500 μg/mL；实验持续时间) 具有约 22 μcm/s 的角膜通透性系数[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ibufenac 相关抗体:
体内研究
(In Vivo)

Ibufenac (10-80 mg/kg；口服给药；实验周期为完成红斑评估所需时间) 在豚鼠紫外线红斑实验中的抗炎效力在 Aspirin (HY-14654) 的 2-4 倍范围内[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (about 150 g weight), female guinea - pigs (500 - 800 g weight), male mice (20 - 25 g weight) for various inflammation - related models such as adjuvant arthritis in rats, formation of granulation tissue in the rat[2]
Dosage: 10, 20, 40, 80 mg/kg (adjuvant arthritis in rats); 80, 160, 320 mg/kg (formation of granulation tissue in the rat)
Administration: Oral administration (p.o.), twice a day (at 9:00 and 16:00 hr), and the cycle varied according to different experiments, for example, 7 days for the formation of granulation tissue experiment in the rat, 19 days for the adjuvant arthritis experiment in the rat after injection of adjuvant
Result: Was twice as active as aspirin but less effective than phenylbutazone in suppressing the development of adjuvant arthritis in the adjuvant arthritis experiment in rats.
Produced a significant reduction in granulation tissue compared with controls, but the effect was more modest compared to hydrocortisone sodium succinate in the formation of granulation tissue experiment in the rat (160 and 320 mg/kg).
分子量

192.26

Formula

C12H16O2
CAS 号
性状

固体

颜色

White to light yellow

中文名称

4-异丁基苯乙酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (520.13 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2013 mL 26.0067 mL 52.0134 mL
5 mM 1.0403 mL 5.2013 mL 10.4027 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.98%

COA (281 KB) HNMR (130 KB) RP-HPLC (260 KB)

产品使用指南 (1538 KB)
参考文献

Ibufenac 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2013 mL 26.0067 mL 52.0134 mL 130.0336 mL
5 mM 1.0403 mL 5.2013 mL 10.4027 mL 26.0067 mL
10 mM 0.5201 mL 2.6007 mL 5.2013 mL 13.0034 mL
15 mM 0.3468 mL 1.7338 mL 3.4676 mL 8.6689 mL
20 mM 0.2601 mL 1.3003 mL 2.6007 mL 6.5017 mL
25 mM 0.2081 mL 1.0403 mL 2.0805 mL 5.2013 mL
30 mM 0.1734 mL 0.8669 mL 1.7338 mL 4.3345 mL
40 mM 0.1300 mL 0.6502 mL 1.3003 mL 3.2508 mL
50 mM 0.1040 mL 0.5201 mL 1.0403 mL 2.6007 mL
60 mM 0.0867 mL 0.4334 mL 0.8669 mL 2.1672 mL
80 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6254 mL
100 mM 0.0520 mL 0.2601 mL 0.5201 mL 1.3003 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ibufenac1553-60-2Dytransin4-异丁基苯乙酸COXCyclooxygenasenon-steroidalanti-rheumatoidanalgesicanti-inflammatoryInhibitorinhibitorinhibit

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