Indecainide hydrochloride  (Synonyms: LY 135837)

Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent^[1].

Indecainide hydrochloride (0, 3, 6, or 9 mg/kg; IV, daily for 1 month) causes 6 of 10 male rats and 1 of 10 female rats die at 9 mg/kg during the test period^[2].
Indecainide hydrochloride (0, 1.5, 3, or 4.5 mg/kg; IV, daily for 1 month) causes 2 of 4 dogs die at 4.5 mg/kg; exhibits no overt signs of toxicity and no hematologic, serum chemistry or histologic changes at 1.5 or 3 mg/kg^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

344.88

C₂₀H₂₅ClN₂O

73681-12-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Steinberg MI, et al. Electrophysiological studies of indecainide hydrochloride, a new antiarrhythmic agent, in canine cardiac tissues. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):614-21.  [Content Brief]

  [2]. Sandusky GE Jr, et al. Toxicology of indecainide hydrochloride after intravenous administration to rats and dogs. Toxicol Lett. 1985 Aug;26(2-3):107-10.  [Content Brief]