Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

Affiliations

• 1 Department of Neurobiology & Behavior, University of California, Irvine , Irvine, CA, USA.
• 2 Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA, USA.
• 3 Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, CA, USA.
• 4 Department of Psychiatry, Perelman School of Medicine , University of Pennsylvania, Philadelphia, PA, USA.
• 5 Pharmacology Graduate Group, Biomedical Graduate Studies Program, University of Pennsylvania , Philadelphia, PA, USA.
• 6 Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania , Philadelphia, PA, USA.
• 7 Neuroscience Graduate Program and Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus , Aurora, CO, USA.
• 8 Department of Biology, The College of New Jersey , Ewing, NJ, USA.
• 9 Department of Neuroscience, Perelman School of Medicine , Philadelphia, PA, USA.
• 10 Department of Pharmaceutical Sciences, University of California, Irvine , Irvine, CA, USA.
• 11 Department of Bioengineering, University of Pennsylvania , Philadelphia, PA, USA.
• 12 Division of Neurology, Children's Hospital of Philadelphia , Philadelphia, PA, USA.
• # Contributed equally.