1. Academic Validation
  2. Association between thyroid hormone resistance and obesity: a cross-sectional study and mouse stimulation test

Association between thyroid hormone resistance and obesity: a cross-sectional study and mouse stimulation test

  • Obesity (Silver Spring). 2024 Aug;32(8):1483-1493. doi: 10.1002/oby.24084.
Zhihui Wang 1 2 3 4 5 6 Huimin Yu 1 2 3 4 5 6 Kai Wang 1 2 3 4 5 6 Junming Han 1 2 3 4 5 6 Yongfeng Song 1 2 3 4 5 6 7
Affiliations

Affiliations

  • 1 Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
  • 2 Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China.
  • 3 Shandong Institute of Endocrine and Metabolic Diseases, Jinan, China.
  • 4 "Chuangxin China" Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease, Jinan, China.
  • 5 Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, China.
  • 6 Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, China.
  • 7 Department of Endocrinology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Abstract

Objective: Thyroid hormone influences key metabolic pathways, and reduced sensitivity to thyroid hormone is considered a new risk factor for adverse metabolic outcomes. However, the association between thyroid hormone resistance and obesity in euthyroid individuals is still unknown.

Methods: We enrolled 8021 euthyroid individuals, calculated thyroid hormone resistance indices, and analyzed the association between thyroid hormone resistance and obesity by regression analysis. Furthermore, we conducted the thyrotropin-releasing hormone stimulation test in both control and obese mice (n = 5) to demonstrate the association.

Results: The euthyroid adults with overweight and obesity had increased thyroid hormone resistance indices (all p < 0.05). BMI and prevalence of overweight and obesity increased (odds ratio of thyroid feedback quantile-based index [ORTFQI] = 1.164, p = 0.036; OR of free triiodothyronine/free thyroxine [ORFT3/FT4] = 1.508, p < 0.001) following the elevation of thyroid hormone resistance indices. Mediation analysis indicated a complete mediation effect (beta coefficient of indirect effect [βInd]= 6.838, p < 0.001) of metabolic disorders in the relationship. Furthermore, in the mice with obesity, the thyrotropin response to thyrotropin-releasing hormone stimulation (68.33-90.89 pg/mL) was comparatively blunted (p = 0.029).

Conclusions: Euthyroid individuals with obesity exhibit both central and peripheral thyroid hormone resistance, a phenomenon that is more pronounced in individuals with metabolic abnormalities. Thyroid hormone resistance is associated with an increased prevalence of overweight and obesity mediated by metabolic disorders.

Figures
Products
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验,部分功能也使用 Cookies 帮助我们更好地理解您的需求,为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问,请阅读我们的《隐私声明》