2. Academic Validation
  3. IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

  • FEBS Lett. 1996 Sep 9;393(1):53-6. doi: 10.1016/0014-5793(96)00835-6.
C Rolling 1,  D Treton,  S Pellegrini,  P Galanaud,  Y Richard
Affiliations

Affiliation

  • 1 INSERM U131, Institut Paris-Sud sur les Cytokines, Clamart, France.
PMID: 8804422 DOI: 10.1016/0014-5793(96)00835-6
Abstract

IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.

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