2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. MDM2-p53-IN-15

MDM2-p53-IN-15 是 MDM2-p53 的抑制剂，其 IC50 值为 26.1 nM。MDM2-p53-IN-15 抑制多种癌细胞的增值并诱导细胞凋亡。MDM2-p53-IN-15 可用于癌症的研究。

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MDM2-p53-IN-15 Chemical Structure

MDM2-p53-IN-15 Chemical Structure

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MDM2-p53-IN-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDM2-p53-IN-15 is a MDM2-p53 inhibitor with an IC50 value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer[1].

IC50 & Target

IC50: 26.1 nM (MDM2-p53)[1]
体外研究
(In Vitro)

MDM2-p53-IN-15 (1–100 μM; 48 h) inhibits HCT116 cells proliferation[1].
MDM2-p53-IN-15 (10-20 μM; 72-96 h) affects SJSA-1, LNCaP and MCF-7 proliferation[1].
MDM2-p53-IN-15 (10-15 μM; 96 h) affects cell death and apoptosis in SJSA1 cells[1].
MDM2-p53-IN-15 (0-1 μM; 1 h 30 min) dissociates MDM2-p53 complexes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2-p53-IN-15 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCT116 cells
Concentration: 1-100 μM
Incubation Time: 48 hours
Result: Showed antiproliferative activity to HCT116 cells with an IC50 value of 18.8 μM.

Cell Proliferation Assay[1]

Cell Line: SJSA-1, LNCaP and MCF-7 cell lines
Concentration: 10-20 μM
Incubation Time: 72 and 96 hours
Result: Inhibited SJSA-1, LNCaP and MCF-7 cells proliferation with IC50 values of 10.7, 11.4 and 9.7 μM, respectively.

Apoptosis Analysis[1]

Cell Line: SJSA-1 cells
Concentration: 10-15 μM
Incubation Time: 96 hours
Result: Approximately 1.3-fold increased LDH releases at a concentration of 15 μM approximately 1.3-fold increased and induced SJSA-1 cells death with loss of volume. Induced accumulation of cells in G0/G1 phase while decreased the percentage of cells in both S and G2/M phases, thus affects cell cycle.

Cell Viability Assay[1]

Cell Line: U87MG and SHSY-5Y cells
Concentration: 0-1 μM
Incubation Time: 1 h 30 min
Result: Selectively inhibited MDM2-p53 PPIs with an IC50 value of 26.1 nM, while inhibited MDM4-p53 PPIs with a lower potency with an IC50 value of 219 nM.
分子量

685.57

Formula

C38H26Cl2N6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDM2-p53-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2-p53-IN-15MDM-2/p53ApoptosisHCT116PPISJSA-1LNCaPMCF-7anti-proliferationapoptosiscell cycleInhibitorinhibitorinhibit

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产品名称：
MDM2-p53-IN-15
目录号：
HY-151172
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