2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Anti-infection
  3. mAChR Opioid Receptor Drug Metabolite Virus Protease
  4. N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d8 hydrochloride  (Synonyms: N-去甲基氯氮平-d8; Norclozapine-d8 hydrochloride; Desmethylclozapine-d8 hydrochloride; Normethylclozapine-d8 hydrochloride)

目录号: HY-G0021S1 纯度: 99.74%
COA 产品使用指南 技术支持

N-Desmethylclozapine-d8 (hydrochloride) 是 N-Desmethylclozapine hydrochloride 的氘代物。N-Desmethylclozapine hydrochloride 是非典型抗精神病有效剂 Clozapine 的主要活性代谢产物。N-Desmethylclozapine hydrochloride 是一种有效的、变构的部分 M1 受体激动剂 (EC50=115 nM)，能通过 M1 受体激活增强海马 N-methyl-d-aspartate (NMDA) 受体电流。N-Desmethylclozapine hydrochloride 也是 δ-opioid 激动剂。

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N-Desmethylclozapine-d<sub>8</sub> hydrochloride Chemical Structure

N-Desmethylclozapine-d8 hydrochloride Chemical Structure

CAS No. : 2705402-91-9

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规格 价格 是否有货 数量
1 mg ￥3200
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Other Forms of N-Desmethylclozapine-d8 hydrochloride:

N-Desmethylclozapine-d8 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Desmethylclozapine-d8 hydrochloride 相关抗体:
分子量

357.31

Formula

C17H10D8Cl2N4
CAS 号
非标记 CAS
性状

固体

颜色

Light yellow to yellow

中文名称

氯氮平EP杂质C-d8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 50 mg/mL (139.93 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7987 mL 13.9935 mL 27.9869 mL
5 mM 0.5597 mL 2.7987 mL 5.5974 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

N-Desmethylclozapine-d8 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7987 mL 13.9935 mL 27.9869 mL 69.9673 mL
5 mM 0.5597 mL 2.7987 mL 5.5974 mL 13.9935 mL
10 mM 0.2799 mL 1.3993 mL 2.7987 mL 6.9967 mL
15 mM 0.1866 mL 0.9329 mL 1.8658 mL 4.6645 mL
20 mM 0.1399 mL 0.6997 mL 1.3993 mL 3.4984 mL
25 mM 0.1119 mL 0.5597 mL 1.1195 mL 2.7987 mL
30 mM 0.0933 mL 0.4664 mL 0.9329 mL 2.3322 mL
40 mM 0.0700 mL 0.3498 mL 0.6997 mL 1.7492 mL
50 mM 0.0560 mL 0.2799 mL 0.5597 mL 1.3993 mL
60 mM 0.0466 mL 0.2332 mL 0.4664 mL 1.1661 mL
80 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8746 mL
100 mM 0.0280 mL 0.1399 mL 0.2799 mL 0.6997 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Desmethylclozapine-d82705402-91-9Norclozapine-d8Desmethylclozapine-d8Normethylclozapine-d8氯氮平EP杂质C-d8mAChROpioid ReceptorDrug MetaboliteVirus ProteaseMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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