1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Stem Cell/Wnt
  2. EGFR STAT
  3. OK2

OK2 是 CCN2/EGFR 相互作用的特异性抑制剂,通过与 CCN2 的 CT 结构域结合,有效阻断 CCN2/EGFR 相互作用。OK2 可用于肾纤维化和慢性肾脏疾病的研究。

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Custom Peptide Synthesis

OK2 Chemical Structure

OK2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥600
In-stock
5 mg ¥1500
In-stock
10 mg ¥2500
In-stock
25 mg ¥4800
In-stock
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100 mg   询价  

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Customer Review

查看 EGFR 亚型特异性产品:

查看 STAT 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research[1].

IC50 & Target

p-STAT3

 

体外研究
(In Vitro)

OK2 (0-100 μM;24 小时) 抑制 HK-2 细胞 EGFR 活化、 STAT3 磷酸化和 ECM 蛋白合成[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HK-2 cells
Concentration: 0, 4, 20, 100 μM
Incubation Time: 24 hours
Result: Blocked thevastmajority ofEGFR activation in therenalfibrosis cell model, thereby preventing EGFRmediated STAT3 phosphorylation andECMprotein synthesis.
Inhibited EGFR-mediated ECM protein synthesis in a dose dependent manner and exhibited a significant blocking effect beginning at 20 μM.
体内研究
(In Vivo)

OK2 (50 μg/kg,腹腔注射,持续 14 天) 在单侧输尿管梗阻 (UUO) 小鼠模型中阻断 CCN2 诱导的 EGFR/STAT3 激活并阻止肾纤维化[1]
OK2 (皮下注射,1 mg/kg) 显示在雄性 Sprague Dawley 大鼠体内 T1/2 为 0.9 小时,C max 为 1057.8 ng/mL[1]
Pharmacokinetic parameters for OK2 in male Sprague Dawley rats [1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) AUC0-t (h•ng/mL)
s.c. 1 1057.8 1.0 0.9 3032.0
Animal Model: Unilateral ureteric obstruction (UUO)-induced renal fibrosis [1]
Dosage: 50 μg/kg
Administration: Intraperitoneal injection (i.p.) for 14 days
Result: Alleviated renal tubular injury and inflammatory infiltration, as well as suppressed collagen formation in the left kidney.
Inhibited the phosphorylation of EGFR and STAT3 and reduced the vast majority of fibronectin and type I collagen synthesis.
Animal Model: Male Sprague Dawley rats(Pharmacokinetic assay)[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Showed a T1/2 of 0.9 h and Cmax of 1057.8 ng/mL in male Sprague Dawley rats[1].
分子量

907.03

Formula

C42H62N14O9

性状

固体

颜色

White to off-white

Sequence

cyclo-(Thr-Lys-His-Arg-Pro-Trp-Thr)

Sequence Shortening

cyclo-(TKHRPWT)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (110.25 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1025 mL 5.5125 mL 11.0250 mL
5 mM 0.2205 mL 1.1025 mL 2.2050 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1025 mL 5.5125 mL 11.0250 mL 27.5625 mL
5 mM 0.2205 mL 1.1025 mL 2.2050 mL 5.5125 mL
10 mM 0.1102 mL 0.5512 mL 1.1025 mL 2.7562 mL
15 mM 0.0735 mL 0.3675 mL 0.7350 mL 1.8375 mL
20 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3781 mL
25 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1025 mL
30 mM 0.0367 mL 0.1837 mL 0.3675 mL 0.9187 mL
40 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6891 mL
50 mM 0.0220 mL 0.1102 mL 0.2205 mL 0.5512 mL
60 mM 0.0184 mL 0.0919 mL 0.1837 mL 0.4594 mL
80 mM 0.0138 mL 0.0689 mL 0.1378 mL 0.3445 mL
100 mM 0.0110 mL 0.0551 mL 0.1102 mL 0.2756 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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OK2
目录号:
HY-P5314
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