2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite Fungal Phosphatase Bacterial Antibiotic
  4. Pentamidine dihydrochloride

Pentamidine dihydrochloride  (Synonyms: 喷他脒二盐酸盐; MP-601205 dihydrochloride)

目录号: HY-B0537A
产品使用指南 技术支持

Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。Pentamidine dihydrochloride 抑制寄生虫 Leishmania infantum，IC50 为 2.5 μM。Pentamidine dihydrochloride 是一种有效的选择性蛋白酪氨酸磷酸酶 (PTPases) 和再生肝磷酸酶 (PRL) 抑制剂。Pentamidine dihydrochloride 可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究。抗肿瘤活性，抗菌活性。

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Pentamidine dihydrochloride Chemical Structure

Pentamidine dihydrochloride Chemical Structure

CAS No. : 50357-45-4

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Pentamidine dihydrochloride 的其他形式现货产品:

Other Forms of Pentamidine dihydrochloride:

Pentamidine dihydrochloride 相关抗体

Top Publications Citing Use of Products

    Pentamidine dihydrochloride purchased from MCE. Usage Cited in: BMC Womens Health. 2022 Nov 24;22(1):470.  [Abstract]

    Pentamidine (2.5, 5 μM; 24-36 h) reduces cell migration in a dose- and time-dependent manner, in Ishikawa and HEC-1A cells.

    查看 Parasite 亚型特异性产品:

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    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

    IC50 & Target

    Trypanosoma

     

    Leishmania

     

    体外研究
    (In Vitro)

    Pentamidine (0-10 µg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner[1].
    The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite Leishmania infantum is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Pentamidine dihydrochloride 相关抗体:

    Cell Viability Assay[1]

    Cell Line: WM9, DU145, C4-2, Hey, WM480, and A549 cells
    Concentration: 0-10 µg/mL
    Incubation Time: 6 days
    Result: The growth of all six of the cell lines in culture was inhibited in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 µg/mL.
    体内研究
    (In Vivo)

    Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Athymic nude mice (6 weeks old) injected with WM9 cells[1]
    Dosage: 0.25 mg/mouse
    Administration: Intramuscular injection; every 2 days; for 4 weeks
    Result: Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.
    Clinical Trial
    分子量

    413.34

    Formula

    C19H26Cl2N4O2
    CAS 号
    中文名称

    喷他脒二盐酸盐；喷它咪二盐酸盐；戊烷脒二盐酸盐；戊脘脒二盐酸盐
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 10 mg/mL (24.19 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.4193 mL 12.0966 mL 24.1932 mL
    5 mM 0.4839 mL 2.4193 mL 4.8386 mL
    查看完整储备液配制表

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Pentamidine dihydrochloride 相关分类

    完整储备液配制表

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.4193 mL 12.0966 mL 24.1932 mL 60.4829 mL
    5 mM 0.4839 mL 2.4193 mL 4.8386 mL 12.0966 mL
    10 mM 0.2419 mL 1.2097 mL 2.4193 mL 6.0483 mL
    15 mM 0.1613 mL 0.8064 mL 1.6129 mL 4.0322 mL
    20 mM 0.1210 mL 0.6048 mL 1.2097 mL 3.0241 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pentamidine50357-45-4MP-601205喷他脒二盐酸盐喷它咪二盐酸盐戊烷脒二盐酸盐戊脘脒二盐酸盐MP601205MP 601205ParasiteFungalPhosphataseBacterialAntibioticKidneyDNAbiosyntheticsPneumocystiscariniipneumoniacell-cyclearrestantitumorPTP1BInhibitorinhibitorinhibit

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