2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite Fungal Phosphatase Bacterial Antibiotic
  4. Pentamidine

Pentamidine  (Synonyms: 喷他脒; MP-601205)

目录号: HY-B0537 纯度: 97.19%
COA 产品使用指南

摩尔计算器

Pentamidine (MP-601205) 是一种抗微生物剂，会干扰 DNA 的生物合成。Pentamidine 抑制寄生虫 Leishmania infantum，IC50 为 2.5 μM。Pentamidine 是一种有效的选择性蛋白酪氨酸磷酸酶 (PTPases) 和再生肝磷酸酶 (PRL) 抑制剂。Pentamidine 可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究。抗肿瘤活性，抗菌活性。

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Pentamidine Chemical Structure

Pentamidine Chemical Structure

CAS No. : 100-33-4

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规格 价格 是否有货 数量
50 mg ￥300
In-stock
100 mg ￥400
In-stock
200 mg   询价  
500 mg   询价  

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Other Forms of Pentamidine:

Pentamidine 相关抗体

Top Publications Citing Use of Products

    Pentamidine purchased from MCE. Usage Cited in: BMC Womens Health. 2022 Nov 24;22(1):470.  [Abstract]

    Pentamidine (2.5, 5 μM; 24-36 h) reduces cell migration in a dose- and time-dependent manner, in Ishikawa and HEC-1A cells.

    查看 Parasite 亚型特异性产品:

    查看所有亚型
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    查看 Antibiotic 亚型特异性产品:

    查看所有亚型
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

    IC50 & Target

    Trypanosoma

     

    Leishmania

     

    体外研究
    (In Vitro)

    Pentamidine (0-10 µg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner[1].
    The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite Leishmania infantum is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Pentamidine 相关抗体:

    Cell Viability Assay[1]

    Cell Line: WM9, DU145, C4-2, Hey, WM480, and A549 cells
    Concentration: 0-10 µg/mL
    Incubation Time: 6 days
    Result: The growth of all six of the cell lines in culture was inhibited in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 µg/mL.
    体内研究
    (In Vivo)

    Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Athymic nude mice (6 weeks old) injected with WM9 cells[1]
    Dosage: 0.25 mg/mouse
    Administration: Intramuscular injection; every 2 days; for 4 weeks
    Result: Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.
    Clinical Trial
    分子量

    340.42

    Formula

    C19H24N4O2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    喷他脒；喷它咪；戊烷脒；戊脘脒
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 6.25 mg/mL (18.36 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.9375 mL 14.6877 mL 29.3755 mL
    5 mM 0.5875 mL 2.9375 mL 5.8751 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 97.19%

    COA (279 KB) HNMR (180 KB) RP-HPLC (138 KB) LCMS (379 KB)

    产品使用指南 (1538 KB)
    参考文献

    Pentamidine 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9375 mL 14.6877 mL 29.3755 mL 73.4387 mL
    5 mM 0.5875 mL 2.9375 mL 5.8751 mL 14.6877 mL
    10 mM 0.2938 mL 1.4688 mL 2.9375 mL 7.3439 mL
    15 mM 0.1958 mL 0.9792 mL 1.9584 mL 4.8959 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pentamidine100-33-4MP-601205喷他脒喷它咪戊烷脒戊脘脒MP601205MP 601205ParasiteFungalPhosphataseBacterialAntibioticKidneyDNAbiosyntheticsPneumocystiscariniipneumoniacell-cyclearrestantitumorPTP1BInhibitorinhibitorinhibit

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    目录号：
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