2. Others Anti-infection Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Parasite Fungal Phosphatase Bacterial Antibiotic
  4. Pentamidine-d4 dihydrochloride

Pentamidine-d4 dihydrochloride  (Synonyms: 喷他脒二盐酸盐-d4; MP-601205-d4(dihydrochloride))

目录号: HY-B0537AS 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Pentamidine-d4 (dihydrochloride) 是 Pentamidine dihydrochloride 的氘代物。Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。Pentamidine dihydrochloride 抑制寄生虫 Leishmania infantum，IC50 为 2.5 μM。Pentamidine dihydrochloride 是一种有效的选择性蛋白酪氨酸磷酸酶 (PTPases) 和再生肝磷酸酶 (PRL) 抑制剂。Pentamidine dihydrochloride 可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究。抗肿瘤活性，抗菌活性。

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Pentamidine-d<sub>4</sub> dihydrochloride Chemical Structure

Pentamidine-d4 dihydrochloride Chemical Structure

CAS No. : 1276197-32-0

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规格 价格 是否有货 数量
1 mg ￥1300
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Customer Review

Other Forms of Pentamidine-d4 dihydrochloride:

Pentamidine-d4 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pentamidine-d4 (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

IC50 & Target

Trypanosoma

 

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pentamidine-d4 dihydrochloride 相关抗体:
分子量

417.37

Formula

C19H22D4Cl2N4O2
CAS 号
非标记 CAS

50357-45-4
性状

固体

颜色

White to off-white

中文名称

喷他脒二盐酸盐-d4；喷它咪二盐酸盐-d4；戊烷脒二盐酸盐-d4；戊脘脒二盐酸盐-d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (23.96 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3960 mL 11.9798 mL 23.9596 mL
5 mM 0.4792 mL 2.3960 mL 4.7919 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (167 KB)

产品使用指南 (1538 KB)
参考文献

Pentamidine-d4 dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3960 mL 11.9798 mL 23.9596 mL 59.8989 mL
5 mM 0.4792 mL 2.3960 mL 4.7919 mL 11.9798 mL
10 mM 0.2396 mL 1.1980 mL 2.3960 mL 5.9899 mL
15 mM 0.1597 mL 0.7987 mL 1.5973 mL 3.9933 mL
20 mM 0.1198 mL 0.5990 mL 1.1980 mL 2.9949 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentamidine-d41276197-32-0MP-601205-d4(dihydrochloride)喷他脒二盐酸盐-d4喷它咪二盐酸盐-d4戊烷脒二盐酸盐-d4戊脘脒二盐酸盐-d4Isotope-Labeled CompoundsParasiteFungalPhosphataseBacterialAntibioticInhibitorinhibitorinhibit

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目录号：
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